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PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells
Cell migration is a fundamental cellular process required for embryonic development to wound healing and also plays a key role in tumor metastasis and atherosclerosis. Migration is regulated at multiple strata, from cytoskeletal reorganization to vesicle trafficking. In migrating cells, signaling pa...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496677/ https://www.ncbi.nlm.nih.gov/pubmed/23076053 http://dx.doi.org/10.4161/cam.21192 |
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author | Thapa, Narendra Anderson, Richard A. |
author_facet | Thapa, Narendra Anderson, Richard A. |
author_sort | Thapa, Narendra |
collection | PubMed |
description | Cell migration is a fundamental cellular process required for embryonic development to wound healing and also plays a key role in tumor metastasis and atherosclerosis. Migration is regulated at multiple strata, from cytoskeletal reorganization to vesicle trafficking. In migrating cells, signaling pathways are integrated with vesicle trafficking machineries in a highly coordinated fashion to accomplish the recruitment and trafficking of the trans-membrane proteins toward the leading edge. Different signaling molecules regulate cell migration in different physio-pathological contexts, among them, phosphatidylinositol-4,5-biphosphate (PIP2) is an integral component of the plasma membrane and pleiotropic lipid signaling molecule modulating diverse biological processes, including actin cytoskeletal dynamics and vesicle trafficking required for cell migration. In this commentary, we provide a brief overview of our current understandings on the phosphoinositide signaling and its implication in regulation of cell polarity and vesicle trafficking in migrating cells. In addition, we highlight the coordinated role of PIPKIγi2, a focal adhesion-targeted enzyme that synthesizes PIP2, and the exocyst complex, a PIP2-effector, in the trafficking of E-cadherin in epithelial cells and integrins in migrating cancer cells. |
format | Online Article Text |
id | pubmed-3496677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-34966772012-11-23 PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells Thapa, Narendra Anderson, Richard A. Cell Adh Migr Commentary Cell migration is a fundamental cellular process required for embryonic development to wound healing and also plays a key role in tumor metastasis and atherosclerosis. Migration is regulated at multiple strata, from cytoskeletal reorganization to vesicle trafficking. In migrating cells, signaling pathways are integrated with vesicle trafficking machineries in a highly coordinated fashion to accomplish the recruitment and trafficking of the trans-membrane proteins toward the leading edge. Different signaling molecules regulate cell migration in different physio-pathological contexts, among them, phosphatidylinositol-4,5-biphosphate (PIP2) is an integral component of the plasma membrane and pleiotropic lipid signaling molecule modulating diverse biological processes, including actin cytoskeletal dynamics and vesicle trafficking required for cell migration. In this commentary, we provide a brief overview of our current understandings on the phosphoinositide signaling and its implication in regulation of cell polarity and vesicle trafficking in migrating cells. In addition, we highlight the coordinated role of PIPKIγi2, a focal adhesion-targeted enzyme that synthesizes PIP2, and the exocyst complex, a PIP2-effector, in the trafficking of E-cadherin in epithelial cells and integrins in migrating cancer cells. Landes Bioscience 2012-09-01 /pmc/articles/PMC3496677/ /pubmed/23076053 http://dx.doi.org/10.4161/cam.21192 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Thapa, Narendra Anderson, Richard A. PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
title | PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
title_full | PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
title_fullStr | PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
title_full_unstemmed | PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
title_short | PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
title_sort | pip2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496677/ https://www.ncbi.nlm.nih.gov/pubmed/23076053 http://dx.doi.org/10.4161/cam.21192 |
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