Inherited gastrointestinal stromal tumor syndromes: mutations, clinical features, and therapeutic implications

The discovery of underlying molecular genetic abnormalities in gastrointestinal stromal tumors (GISTs) such as activating mutations in the tyrosine kinase genes, KIT and platelet derived growth factor receptor-alpha (PDGFRA), has led to remarkable clinical advances in treatment. Small molecule inhib...

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Detalles Bibliográficos
Autores principales: Postow, Michael A, Robson, Mark E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496697/
https://www.ncbi.nlm.nih.gov/pubmed/23036227
http://dx.doi.org/10.1186/2045-3329-2-16

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