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Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design
OBJECTIVE: Ginger effects on (experimental) nausea have been described, but also strong placebo effects and sex differences when nausea is involved. The “balanced placebo design” has been proposed to allow better separation of drug and placebo effects. METHODS: Sixty-four healthy participants (32 wo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496739/ https://www.ncbi.nlm.nih.gov/pubmed/23152846 http://dx.doi.org/10.1371/journal.pone.0049031 |
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author | Weimer, Katja Schulte, Jörg Maichle, Annamaria Muth, Eric R. Scisco, Jenna L. Horing, Björn Enck, Paul Klosterhalfen, Sibylle |
author_facet | Weimer, Katja Schulte, Jörg Maichle, Annamaria Muth, Eric R. Scisco, Jenna L. Horing, Björn Enck, Paul Klosterhalfen, Sibylle |
author_sort | Weimer, Katja |
collection | PubMed |
description | OBJECTIVE: Ginger effects on (experimental) nausea have been described, but also strong placebo effects and sex differences when nausea is involved. The “balanced placebo design” has been proposed to allow better separation of drug and placebo effects. METHODS: Sixty-four healthy participants (32 women) were randomly assigned to receive an antiemetic ginger preparation or placebo, and half of each group was told to have received drug or placebo. They were exposed to 5×2 min body rotations to induce nausea. Subjective symptoms and behavioral (rotation tolerance, head movements) and physiological measures (electrogastrogram, cortisol) were recorded. Groups were balanced for sex of participants and experimenters. RESULTS: Ginger and the information given did not affect any outcome measure, and previous sex differences could not be confirmed. Adding the experimenters revealed a significant four-factorial interaction on behavioral but not on subjective or physiological measures Men who received placebo responded to placebo information when provided by the male experimenter, and to ginger information when provided by the female experimenter. This effect was not significant in women. CONCLUSION: The effects of an antiemetic drug and provided information interact with psychosocial variables of participants and experimenters in reports of nausea. |
format | Online Article Text |
id | pubmed-3496739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34967392012-11-14 Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design Weimer, Katja Schulte, Jörg Maichle, Annamaria Muth, Eric R. Scisco, Jenna L. Horing, Björn Enck, Paul Klosterhalfen, Sibylle PLoS One Research Article OBJECTIVE: Ginger effects on (experimental) nausea have been described, but also strong placebo effects and sex differences when nausea is involved. The “balanced placebo design” has been proposed to allow better separation of drug and placebo effects. METHODS: Sixty-four healthy participants (32 women) were randomly assigned to receive an antiemetic ginger preparation or placebo, and half of each group was told to have received drug or placebo. They were exposed to 5×2 min body rotations to induce nausea. Subjective symptoms and behavioral (rotation tolerance, head movements) and physiological measures (electrogastrogram, cortisol) were recorded. Groups were balanced for sex of participants and experimenters. RESULTS: Ginger and the information given did not affect any outcome measure, and previous sex differences could not be confirmed. Adding the experimenters revealed a significant four-factorial interaction on behavioral but not on subjective or physiological measures Men who received placebo responded to placebo information when provided by the male experimenter, and to ginger information when provided by the female experimenter. This effect was not significant in women. CONCLUSION: The effects of an antiemetic drug and provided information interact with psychosocial variables of participants and experimenters in reports of nausea. Public Library of Science 2012-11-13 /pmc/articles/PMC3496739/ /pubmed/23152846 http://dx.doi.org/10.1371/journal.pone.0049031 Text en © 2012 Weimer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Weimer, Katja Schulte, Jörg Maichle, Annamaria Muth, Eric R. Scisco, Jenna L. Horing, Björn Enck, Paul Klosterhalfen, Sibylle Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design |
title | Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design |
title_full | Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design |
title_fullStr | Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design |
title_full_unstemmed | Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design |
title_short | Effects of Ginger and Expectations on Symptoms of Nausea in a Balanced Placebo Design |
title_sort | effects of ginger and expectations on symptoms of nausea in a balanced placebo design |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496739/ https://www.ncbi.nlm.nih.gov/pubmed/23152846 http://dx.doi.org/10.1371/journal.pone.0049031 |
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