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Physical constraints on the establishment of intracellular spatial gradients in bacteria

BACKGROUND: Bacteria dynamically regulate their intricate intracellular organization involving proteins that facilitate cell division, motility, and numerous other processes. Consistent with this sophisticated organization, bacteria are able to create asymmetries and spatial gradients of proteins by...

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Detalles Bibliográficos
Autores principales: Tropini, Carolina, Rabbani, Naveed, Huang, Kerwyn Casey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496868/
https://www.ncbi.nlm.nih.gov/pubmed/22931750
http://dx.doi.org/10.1186/2046-1682-5-17
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author Tropini, Carolina
Rabbani, Naveed
Huang, Kerwyn Casey
author_facet Tropini, Carolina
Rabbani, Naveed
Huang, Kerwyn Casey
author_sort Tropini, Carolina
collection PubMed
description BACKGROUND: Bacteria dynamically regulate their intricate intracellular organization involving proteins that facilitate cell division, motility, and numerous other processes. Consistent with this sophisticated organization, bacteria are able to create asymmetries and spatial gradients of proteins by localizing signaling pathway components. We use mathematical modeling to investigate the biochemical and physical constraints on the generation of intracellular gradients by the asymmetric localization of a source and a sink. RESULTS: We present a systematic computational analysis of the effects of other regulatory mechanisms, such as synthesis, degradation, saturation, and cell growth. We also demonstrate that gradients can be established in a variety of bacterial morphologies such as rods, crescents, spheres, branched and constricted cells. CONCLUSIONS: Taken together, these results suggest that gradients are a robust and potentially common mechanism for providing intracellular spatial cues.
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spelling pubmed-34968682012-11-16 Physical constraints on the establishment of intracellular spatial gradients in bacteria Tropini, Carolina Rabbani, Naveed Huang, Kerwyn Casey BMC Biophys Research Article BACKGROUND: Bacteria dynamically regulate their intricate intracellular organization involving proteins that facilitate cell division, motility, and numerous other processes. Consistent with this sophisticated organization, bacteria are able to create asymmetries and spatial gradients of proteins by localizing signaling pathway components. We use mathematical modeling to investigate the biochemical and physical constraints on the generation of intracellular gradients by the asymmetric localization of a source and a sink. RESULTS: We present a systematic computational analysis of the effects of other regulatory mechanisms, such as synthesis, degradation, saturation, and cell growth. We also demonstrate that gradients can be established in a variety of bacterial morphologies such as rods, crescents, spheres, branched and constricted cells. CONCLUSIONS: Taken together, these results suggest that gradients are a robust and potentially common mechanism for providing intracellular spatial cues. BioMed Central 2012-08-29 /pmc/articles/PMC3496868/ /pubmed/22931750 http://dx.doi.org/10.1186/2046-1682-5-17 Text en Copyright ©2012 Tropini et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tropini, Carolina
Rabbani, Naveed
Huang, Kerwyn Casey
Physical constraints on the establishment of intracellular spatial gradients in bacteria
title Physical constraints on the establishment of intracellular spatial gradients in bacteria
title_full Physical constraints on the establishment of intracellular spatial gradients in bacteria
title_fullStr Physical constraints on the establishment of intracellular spatial gradients in bacteria
title_full_unstemmed Physical constraints on the establishment of intracellular spatial gradients in bacteria
title_short Physical constraints on the establishment of intracellular spatial gradients in bacteria
title_sort physical constraints on the establishment of intracellular spatial gradients in bacteria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496868/
https://www.ncbi.nlm.nih.gov/pubmed/22931750
http://dx.doi.org/10.1186/2046-1682-5-17
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