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Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome

Patients developing the short bowel syndrome (SBS) are at risk for hepatobiliary disease, as are morbidly obese individuals. We hypothesized that morbidly obese SBS individuals would be at increased risk for developing hepatobiliary complications. We reviewed 79 patients with SBS, 53 patients with i...

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Autores principales: Thompson, Jon S., Weseman, Rebecca A., Rochling, Fedja A., Grant, Wendy J., Botha, Jean F., Langnas, Alan N., Mercer, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496999/
https://www.ncbi.nlm.nih.gov/pubmed/23201759
http://dx.doi.org/10.3390/nu4101358
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author Thompson, Jon S.
Weseman, Rebecca A.
Rochling, Fedja A.
Grant, Wendy J.
Botha, Jean F.
Langnas, Alan N.
Mercer, David F.
author_facet Thompson, Jon S.
Weseman, Rebecca A.
Rochling, Fedja A.
Grant, Wendy J.
Botha, Jean F.
Langnas, Alan N.
Mercer, David F.
author_sort Thompson, Jon S.
collection PubMed
description Patients developing the short bowel syndrome (SBS) are at risk for hepatobiliary disease, as are morbidly obese individuals. We hypothesized that morbidly obese SBS individuals would be at increased risk for developing hepatobiliary complications. We reviewed 79 patients with SBS, 53 patients with initial body mass index (BMI) < 35 were controls. Twenty-six patients with initial BMI > 35 were the obese group. Obese patients were more likely to be weaned off parenteral nutrition (PN) (58% vs. 21%). Pre-resection BMI was significantly lower in controls (26 vs. 41). BMI at 1, 2, and 5 years was decreased in controls but persistently increased in obese patients. Obese patients were more likely to undergo cholecystectomy prior to SBS (42% vs. 32%) and after SBS (80% vs. 39%, p < 0.05). Fatty liver was more frequent in the obese group prior to SBS (23% vs. 0%, p < 0.05) but was similar to controls after SBS (23% vs. 15%). Fibrosis (8% vs. 13%) and cirrhosis/portal hypertension (19% vs. 21%) were similar in obese and control groups. Overall, end stage liver disease (ESLD) was similar in obese and control groups (19% vs. 11%) but was significantly higher in obese patients receiving PN (45% vs. 14%, p < 0.05). Obese patients developing SBS are at increased risk of developing hepatobiliary complications. ESLD was similar in the two groups overall but occurs more frequently in obese patients maintained on chronic PN.
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spelling pubmed-34969992012-11-29 Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome Thompson, Jon S. Weseman, Rebecca A. Rochling, Fedja A. Grant, Wendy J. Botha, Jean F. Langnas, Alan N. Mercer, David F. Nutrients Article Patients developing the short bowel syndrome (SBS) are at risk for hepatobiliary disease, as are morbidly obese individuals. We hypothesized that morbidly obese SBS individuals would be at increased risk for developing hepatobiliary complications. We reviewed 79 patients with SBS, 53 patients with initial body mass index (BMI) < 35 were controls. Twenty-six patients with initial BMI > 35 were the obese group. Obese patients were more likely to be weaned off parenteral nutrition (PN) (58% vs. 21%). Pre-resection BMI was significantly lower in controls (26 vs. 41). BMI at 1, 2, and 5 years was decreased in controls but persistently increased in obese patients. Obese patients were more likely to undergo cholecystectomy prior to SBS (42% vs. 32%) and after SBS (80% vs. 39%, p < 0.05). Fatty liver was more frequent in the obese group prior to SBS (23% vs. 0%, p < 0.05) but was similar to controls after SBS (23% vs. 15%). Fibrosis (8% vs. 13%) and cirrhosis/portal hypertension (19% vs. 21%) were similar in obese and control groups. Overall, end stage liver disease (ESLD) was similar in obese and control groups (19% vs. 11%) but was significantly higher in obese patients receiving PN (45% vs. 14%, p < 0.05). Obese patients developing SBS are at increased risk of developing hepatobiliary complications. ESLD was similar in the two groups overall but occurs more frequently in obese patients maintained on chronic PN. MDPI 2012-09-26 /pmc/articles/PMC3496999/ /pubmed/23201759 http://dx.doi.org/10.3390/nu4101358 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Thompson, Jon S.
Weseman, Rebecca A.
Rochling, Fedja A.
Grant, Wendy J.
Botha, Jean F.
Langnas, Alan N.
Mercer, David F.
Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome
title Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome
title_full Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome
title_fullStr Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome
title_full_unstemmed Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome
title_short Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome
title_sort preresection obesity increases the risk of hepatobiliary complications in short bowel syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496999/
https://www.ncbi.nlm.nih.gov/pubmed/23201759
http://dx.doi.org/10.3390/nu4101358
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