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Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence

EGFR is the best studied receptor tyrosine kinase. Yet, a comprehensive mechanistic understanding of EGFR signaling is lacking, despite very active research in the field. In this paper, we investigate the role of the juxtamembrane (JM) domain in EGFR signaling by replacing it with a (GGS)(10) unstru...

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Detalles Bibliográficos
Autores principales:	He, Lijuan, Hristova, Kalina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497011/ https://www.ncbi.nlm.nih.gov/pubmed/23152945 http://dx.doi.org/10.1038/srep00854

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