Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans

Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stere...

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Autores principales: Andrianasolo, Eric H., Haramaty, Liti, Rosario-Passapera, Richard, Vetriani, Costantino, Falkowski, Paul, White, Eileen, Lutz, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497024/
https://www.ncbi.nlm.nih.gov/pubmed/23170085
http://dx.doi.org/10.3390/md10102300
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author Andrianasolo, Eric H.
Haramaty, Liti
Rosario-Passapera, Richard
Vetriani, Costantino
Falkowski, Paul
White, Eileen
Lutz, Richard
author_facet Andrianasolo, Eric H.
Haramaty, Liti
Rosario-Passapera, Richard
Vetriani, Costantino
Falkowski, Paul
White, Eileen
Lutz, Richard
author_sort Andrianasolo, Eric H.
collection PubMed
description Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.
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spelling pubmed-34970242012-11-20 Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans Andrianasolo, Eric H. Haramaty, Liti Rosario-Passapera, Richard Vetriani, Costantino Falkowski, Paul White, Eileen Lutz, Richard Mar Drugs Article Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans. MDPI 2012-10-19 /pmc/articles/PMC3497024/ /pubmed/23170085 http://dx.doi.org/10.3390/md10102300 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Andrianasolo, Eric H.
Haramaty, Liti
Rosario-Passapera, Richard
Vetriani, Costantino
Falkowski, Paul
White, Eileen
Lutz, Richard
Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
title Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
title_full Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
title_fullStr Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
title_full_unstemmed Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
title_short Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
title_sort ammonificins c and d, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, thermovibrio ammonificans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497024/
https://www.ncbi.nlm.nih.gov/pubmed/23170085
http://dx.doi.org/10.3390/md10102300
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