Cargando…
The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats
Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-oper...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497268/ https://www.ncbi.nlm.nih.gov/pubmed/23202894 http://dx.doi.org/10.3390/ijms131012224 |
_version_ | 1782249724886122496 |
---|---|
author | Chen, Ming-Jenn Chen, Tzu-Yu Cheng, Ya-Min Hsu, Yi-Chiang |
author_facet | Chen, Ming-Jenn Chen, Tzu-Yu Cheng, Ya-Min Hsu, Yi-Chiang |
author_sort | Chen, Ming-Jenn |
collection | PubMed |
description | Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 × 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion. |
format | Online Article Text |
id | pubmed-3497268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-34972682012-11-29 The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats Chen, Ming-Jenn Chen, Tzu-Yu Cheng, Ya-Min Hsu, Yi-Chiang Int J Mol Sci Article Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 × 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion. Molecular Diversity Preservation International (MDPI) 2012-09-25 /pmc/articles/PMC3497268/ /pubmed/23202894 http://dx.doi.org/10.3390/ijms131012224 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0). |
spellingShingle | Article Chen, Ming-Jenn Chen, Tzu-Yu Cheng, Ya-Min Hsu, Yi-Chiang The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats |
title | The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats |
title_full | The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats |
title_fullStr | The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats |
title_full_unstemmed | The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats |
title_short | The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats |
title_sort | effect of postoperative hyperbaric oxygen treatment on intra-abdominal adhesions in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497268/ https://www.ncbi.nlm.nih.gov/pubmed/23202894 http://dx.doi.org/10.3390/ijms131012224 |
work_keys_str_mv | AT chenmingjenn theeffectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT chentzuyu theeffectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT chengyamin theeffectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT hsuyichiang theeffectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT chenmingjenn effectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT chentzuyu effectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT chengyamin effectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats AT hsuyichiang effectofpostoperativehyperbaricoxygentreatmentonintraabdominaladhesionsinrats |