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Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders
Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497278/ https://www.ncbi.nlm.nih.gov/pubmed/23202904 http://dx.doi.org/10.3390/ijms131012383 |
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author | Zakrzewicz, Dariusz Zakrzewicz, Anna Preissner, Klaus T. Markart, Philipp Wygrecka, Malgorzata |
author_facet | Zakrzewicz, Dariusz Zakrzewicz, Anna Preissner, Klaus T. Markart, Philipp Wygrecka, Malgorzata |
author_sort | Zakrzewicz, Dariusz |
collection | PubMed |
description | Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease. |
format | Online Article Text |
id | pubmed-3497278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-34972782012-11-29 Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders Zakrzewicz, Dariusz Zakrzewicz, Anna Preissner, Klaus T. Markart, Philipp Wygrecka, Malgorzata Int J Mol Sci Review Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease. Molecular Diversity Preservation International (MDPI) 2012-09-27 /pmc/articles/PMC3497278/ /pubmed/23202904 http://dx.doi.org/10.3390/ijms131012383 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0). |
spellingShingle | Review Zakrzewicz, Dariusz Zakrzewicz, Anna Preissner, Klaus T. Markart, Philipp Wygrecka, Malgorzata Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title | Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_full | Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_fullStr | Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_full_unstemmed | Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_short | Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders |
title_sort | protein arginine methyltransferases (prmts): promising targets for the treatment of pulmonary disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497278/ https://www.ncbi.nlm.nih.gov/pubmed/23202904 http://dx.doi.org/10.3390/ijms131012383 |
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