Cargando…

Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer

Semaphorin4D (SEMA4D) has been regarded as an important protein in tumor angiogenesis, though originally identified in neurodevelopment. SEMA4D is extensively expressed in several malignant solid tumors. Nevertheless, the function and expression of SEMA4D in epithelial ovarian cancer (EOC) is as yet...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ying, Zhang, Lei, Pan, Yi, Ren, Xiubao, Hao, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497325/
https://www.ncbi.nlm.nih.gov/pubmed/23202951
http://dx.doi.org/10.3390/ijms131013264
_version_ 1782249738183114752
author Chen, Ying
Zhang, Lei
Pan, Yi
Ren, Xiubao
Hao, Quan
author_facet Chen, Ying
Zhang, Lei
Pan, Yi
Ren, Xiubao
Hao, Quan
author_sort Chen, Ying
collection PubMed
description Semaphorin4D (SEMA4D) has been regarded as an important protein in tumor angiogenesis, though originally identified in neurodevelopment. SEMA4D is extensively expressed in several malignant solid tumors. Nevertheless, the function and expression of SEMA4D in epithelial ovarian cancer (EOC) is as yet not well understood. The aim of this study was to investigate SEMA4D expression in EOC and evaluate its clinical–pathological and prognostic significance. Immunohistochemistry was used to analyze SEMA4D expression and tumor angiogenesis-related proteins (HIF-1α and VEGF) in tissues from 40 patients with normal ovarian epithelia and 124 EOC patients. SEMA4D was found to be expressed in 61.3% of the 124 EOC tissues, which was significantly higher than in the normal ovarian epithelia (p < 0.001). SEMA4D expression correlated with HIF-1α and VEGF closely (ρ = 0.349 and 0.263, p < 0.001). Positive SEMA4D staining was significantly higher in tissues from patients with low histological grade, FIGO stage III-IV, lymph node metastasis and residual disease ≥1 cm (p < 0.05). In the Cox proportional hazard mode, SEMA4D expression and histologic grade were independent indicators of overall survival (OS) and progress-free survival (PFS) for EOC patients. These findings suggest that the cooperation of SEMA4D, HIF-1α, and VEGF may indicate poor prognosis for patients with EOC, thereby demonstrating that SEMA4D and its role in angiogenesis in EOC warrants further study.
format Online
Article
Text
id pubmed-3497325
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-34973252012-11-29 Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer Chen, Ying Zhang, Lei Pan, Yi Ren, Xiubao Hao, Quan Int J Mol Sci Article Semaphorin4D (SEMA4D) has been regarded as an important protein in tumor angiogenesis, though originally identified in neurodevelopment. SEMA4D is extensively expressed in several malignant solid tumors. Nevertheless, the function and expression of SEMA4D in epithelial ovarian cancer (EOC) is as yet not well understood. The aim of this study was to investigate SEMA4D expression in EOC and evaluate its clinical–pathological and prognostic significance. Immunohistochemistry was used to analyze SEMA4D expression and tumor angiogenesis-related proteins (HIF-1α and VEGF) in tissues from 40 patients with normal ovarian epithelia and 124 EOC patients. SEMA4D was found to be expressed in 61.3% of the 124 EOC tissues, which was significantly higher than in the normal ovarian epithelia (p < 0.001). SEMA4D expression correlated with HIF-1α and VEGF closely (ρ = 0.349 and 0.263, p < 0.001). Positive SEMA4D staining was significantly higher in tissues from patients with low histological grade, FIGO stage III-IV, lymph node metastasis and residual disease ≥1 cm (p < 0.05). In the Cox proportional hazard mode, SEMA4D expression and histologic grade were independent indicators of overall survival (OS) and progress-free survival (PFS) for EOC patients. These findings suggest that the cooperation of SEMA4D, HIF-1α, and VEGF may indicate poor prognosis for patients with EOC, thereby demonstrating that SEMA4D and its role in angiogenesis in EOC warrants further study. Molecular Diversity Preservation International (MDPI) 2012-10-16 /pmc/articles/PMC3497325/ /pubmed/23202951 http://dx.doi.org/10.3390/ijms131013264 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0).
spellingShingle Article
Chen, Ying
Zhang, Lei
Pan, Yi
Ren, Xiubao
Hao, Quan
Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
title Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
title_full Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
title_fullStr Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
title_full_unstemmed Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
title_short Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
title_sort over-expression of semaphorin4d, hypoxia-inducible factor-1α and vascular endothelial growth factor is related to poor prognosis in ovarian epithelial cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497325/
https://www.ncbi.nlm.nih.gov/pubmed/23202951
http://dx.doi.org/10.3390/ijms131013264
work_keys_str_mv AT chenying overexpressionofsemaphorin4dhypoxiainduciblefactor1aandvascularendothelialgrowthfactorisrelatedtopoorprognosisinovarianepithelialcancer
AT zhanglei overexpressionofsemaphorin4dhypoxiainduciblefactor1aandvascularendothelialgrowthfactorisrelatedtopoorprognosisinovarianepithelialcancer
AT panyi overexpressionofsemaphorin4dhypoxiainduciblefactor1aandvascularendothelialgrowthfactorisrelatedtopoorprognosisinovarianepithelialcancer
AT renxiubao overexpressionofsemaphorin4dhypoxiainduciblefactor1aandvascularendothelialgrowthfactorisrelatedtopoorprognosisinovarianepithelialcancer
AT haoquan overexpressionofsemaphorin4dhypoxiainduciblefactor1aandvascularendothelialgrowthfactorisrelatedtopoorprognosisinovarianepithelialcancer