Cargando…

Temporally distinct roles for tumor suppressor pathways in cell cycle arrest and cellular senescence in Cyclin D1-driven tumor

BACKGROUND: Cellular senescence represents a tumor suppressive response to a variety of aberrant and oncogenic insults. We have previously described a transgenic mouse model of Cyclin D1-driven senescence in pineal cells that opposes tumor progression. We now attempted to define the molecular mechan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zalzali, Hasan, Harajly, Mohamad, Abdul-Latif, Lina, El-Chaar, Nader, Dbaibo, Ghassan, Skapek, Stephen X, Saab, Raya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497584/ https://www.ncbi.nlm.nih.gov/pubmed/22548705 http://dx.doi.org/10.1186/1476-4598-11-28

Ejemplares similares

p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells
por: Harajly, Mohamad, et al.
Publicado: (2016)

The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486
por: Ghamloush, Farah, et al.
Publicado: (2019)

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
por: Narasimha, Anil M, et al.
Publicado: (2014)

The ING tumor suppressors in cellular senescence and chromatin
por: Ludwig, Susann, et al.
Publicado: (2011)

Cellular Senescence: Many Roads, One Final Destination
por: Saab, Raya
Publicado: (2010)

Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence
por: Dillenburg, Caroline Siviero, et al.
Publicado: (2015)

CD147 Promotes Tumorigenesis via Exosome-Mediated Signaling in Rhabdomyosarcoma
por: Fahs, Assil, et al.
Publicado: (2022)

Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers
por: Elliman, S J, et al.
Publicado: (2014)

Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment
por: Foggetti, Giorgia, et al.
Publicado: (2022)

F box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest
por: Chen, Bill B., et al.
Publicado: (2011)

Frequency of conjugative transfer of plasmid-encoded ISEcp1 - bla(CTX-M-15 )and aac(6')-lb-cr genes in Enterobacteriaceae at a tertiary care center in Lebanon - role of transferases
por: Harajly, Mohamad, et al.
Publicado: (2010)

Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy
por: Rodriguez-Brenes, Ignacio A., et al.
Publicado: (2015)

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
por: Leontieva, Olga V., et al.
Publicado: (2014)

The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression
por: Yang, Yong-Jin, et al.
Publicado: (2010)

Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models
por: Rouland, Lila, et al.
Publicado: (2021)

PTEN: Tumor Suppressor and Metabolic Regulator
por: Chen, Chien-Yu, et al.
Publicado: (2018)

Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest
por: Choi, Jae-Sun, et al.
Publicado: (2018)

KSHV vCyclin Counters the Senescence/G1 Arrest Response Triggered by NF-κB Hyper-activation
por: Zhi, Huijun, et al.
Publicado: (2014)

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
por: Blagosklonny, Mikhail V.
Publicado: (2012)

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence
por: Miyajima, Chiharu, et al.
Publicado: (2020)

XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence
por: Innes, Andrew J., et al.
Publicado: (2021)

The ARF tumor suppressor controls Drosha translation to prevent Ras-driven transformation
por: Kuchenreuther, Michael J., et al.
Publicado: (2013)

Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma
por: Wang, Yanxiao, et al.
Publicado: (2017)

Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence
por: Wang, Zhu, et al.
Publicado: (2019)

CyclinD1 Is a New Target Gene of Tumor Suppressor MiR-520e in Breast Cancer
por: Liang, Quan, et al.
Publicado: (2019)

Molecular analysis of cyclin D1 modulators PRKN and FBX4 as candidate tumor suppressors in sporadic parathyroid adenomas
por: Brewer, Kelly, et al.
Publicado: (2021)

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3
por: Lahtela, Jenni, et al.
Publicado: (2013)

Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor suppressor activities
por: Kagawa, Shingo, et al.
Publicado: (2014)

Correction: Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence
por: Wang, Zhu, et al.
Publicado: (2020)

MicroRNA-505-5p functions as a tumor suppressor by targeting cyclin-dependent kinase 5 in cervical cancer
por: Kapora, Elena, et al.
Publicado: (2019)

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
por: Enrico, Taylor P, et al.
Publicado: (2021)

At the double for tumor suppressor
por: Sonawane, Mahendra
Publicado: (2016)

β-Carboline dimers inhibit the tumor proliferation by the cell cycle arrest of sarcoma through intercalating to Cyclin-A2
por: Ma, Huiya, et al.
Publicado: (2022)

Linking the p53 tumor suppressor pathway to somatic cell reprogramming
por: Kawamura, Teruhisa, et al.
Publicado: (2009)

Hypoxia-Driven Immune Escape in the Tumor Microenvironment
por: Vito, Alyssa, et al.
Publicado: (2020)

Novel Tumor Suppressor lncRNA Growth Arrest-Specific 5 (GAS5) In Human Cancer
por: Yu, Yaya, et al.
Publicado: (2019)

Senescence and tumor suppression
por: Hinds, Philip, et al.
Publicado: (2017)

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway
por: Dbaibo, Ghassan S., et al.
Publicado: (1997)

Cell cycle arrest is not senescence
por: Blagosklonny, Mikhail V.
Publicado: (2011)

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
por: Coppé, Jean-Philippe, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_c6mehmnujmrtoocg5qkl02rea3