Cargando…

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling

Mitochondrial uncoupling is implicated in many patho(physiological) states. Using confocal live cell imaging and an optical O(2) sensing technique, we show that moderate uncoupling of the mitochondria with plecomacrolide Baf (bafilomycin A1) causes partial depolarization of the mitochondria and deep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhdanov, Alexander V., Dmitriev, Ruslan I., Papkovsky, Dmitri B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497721/ https://www.ncbi.nlm.nih.gov/pubmed/22943412 http://dx.doi.org/10.1042/BSR20120085

Ejemplares similares

Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria
por: Zhdanov, Alexander V., et al.
Publicado: (2010)

Optical probes and techniques for O(2) measurement in live cells and tissue
por: Dmitriev, Ruslan I., et al.
Publicado: (2012)

Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes
por: Andreev, Dmitry E, et al.
Publicado: (2015)

Use of Fluorescence Lifetime Imaging Microscopy (FLIM) as a Timer of Cell Cycle S Phase
por: Okkelman, Irina A., et al.
Publicado: (2016)

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons
por: Redmann, Matthew, et al.
Publicado: (2016)

Complexes of Ir(III)-Octaethylporphyrin with Peptides as Probes for Sensing Cellular O(2)
por: Koren, Klaus, et al.
Publicado: (2012)

A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses
por: Okkelman, Irina A., et al.
Publicado: (2019)

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
por: Papkovskaia, Tatiana D., et al.
Publicado: (2012)

Molecular basis of V-ATPase inhibition by bafilomycin A1
por: Wang, Rong, et al.
Publicado: (2021)

Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling
por: Fedele, Anthony O., et al.
Publicado: (2020)

Analysis of tumour oxygenation in model animals on a phosphorescence lifetime based macro-imager
por: Zhdanov, Alexander V., et al.
Publicado: (2023)

Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells
por: Uchenunu, Oro, et al.
Publicado: (2022)

Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection
por: Sabino, Catarina, et al.
Publicado: (2019)

The mitochondrial uncoupling proteins
por: Ledesma, Amalia, et al.
Publicado: (2002)

Bafilomycin A1 Accelerates Chronic Refractory Wound Healing in db/db Mice
por: Wang, Fan, et al.
Publicado: (2020)

Effect of mitochondrial uncouplers niclosamide ethanolamine (NEN) and oxyclozanide on hepatic metastasis of colon cancer
por: Alasadi, Amer, et al.
Publicado: (2018)

Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans
por: Cho, Injeong, et al.
Publicado: (2017)

Uncoupling mitochondrial uncoupling from alternative substrate utilization: implications for heavy intensity exercise
por: Goulding, Richie P., et al.
Publicado: (2020)

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling
por: Ježek, Petr, et al.
Publicado: (2018)

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways
por: Yan, Yumei, et al.
Publicado: (2016)

Organization and characterization of a biosynthetic gene cluster for bafilomycin from Streptomyces griseus DSM 2608
por: Hwang, Jae Yoon, et al.
Publicado: (2013)

Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii
por: Li, Zhong, et al.
Publicado: (2021)

Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells
por: Kamel, Khalid, et al.
Publicado: (2020)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: Novel considerations
por: Juhász, Gábor
Publicado: (2012)

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice
por: Was, Halina, et al.
Publicado: (2016)

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification
por: Yu, Shi, et al.
Publicado: (2020)

Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1
por: Zhu, Jinhong, et al.
Publicado: (2023)

Mitochondrial uncoupling proteins and energy metabolism
por: Busiello, Rosa A., et al.
Publicado: (2015)

Circadian regulation of mitochondrial uncoupling and lifespan
por: Ulgherait, Matt, et al.
Publicado: (2020)

Circadian Regulation of Mitochondrial Uncoupling and Lifespan
por: Ulgherait, Matthew
Publicado: (2020)

Interaction of Potent Mitochondrial Uncouplers with Thiol-Containing Antioxidants
por: Khailova, Ljudmila S., et al.
Publicado: (2019)

The (pro)renin receptor mediates constitutive PLZF-independent pro-proliferative effects which are inhibited by bafilomycin but not genistein
por: KIRSCH, SEBASTIAN, et al.
Publicado: (2014)

The Autophagic Flux Inhibitor Bafilomycine A1 Affects the Expression of Intermediary Metabolism-Related Genes in Trout Hepatocytes
por: Séité, Sarah, et al.
Publicado: (2019)

0035. Mitochondrial uncoupling contributes to fever in sepsis
por: Greco, E, et al.
Publicado: (2014)

Exploring the therapeutic potential of mitochondrial uncouplers in cancer
por: Shrestha, Riya, et al.
Publicado: (2021)

Draft Genome Sequence of Kitasatospora griseola Strain MF730-N6, a Bafilomycin, Terpentecin, and Satosporin Producer
por: Arens, Jennifer C., et al.
Publicado: (2015)

Bafilomycin A1 inhibits SARS-CoV-2 infection in a human lung xenograft mouse model
por: Zhang, Cuiling, et al.
Publicado: (2023)

Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition
por: Kharechkina, Ekaterina S., et al.
Publicado: (2021)

Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context
por: Benitez-Cantos, Maria S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b63erhmg1feh7q9qbc3jhs4a4f