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Expression of a glycosylphosphatidylinositol-anchored ligand, growth hormone, blocks receptor signalling

We have investigated the interaction between GH (growth hormone) and GHR (GH receptor). We previously demonstrated that a truncated GHR that possesses a transmembrane domain but no cytoplasmic domain blocks receptor signalling. Based on this observation we investigated the impact of tethering the re...

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Detalles Bibliográficos
Autores principales:	Guesdon, François, Kaabi, Yahia, Riley, Aiden H., Wilkinson, Ian R., Gray, Colin, James, David C., Artymiuk, Peter J., Sayers, Jon R., Ross, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497723/ https://www.ncbi.nlm.nih.gov/pubmed/23013472 http://dx.doi.org/10.1042/BSR20120088

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