Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzyme

Cu,Zn SOD1 (superoxide dismutase 1) is implicated in FALS (familial amyotrophic lateral sclerosis) through the accumulation of misfolded proteins that are toxic to neuronal cells. Loop VI (residues 102–115) of the protein is at the dimer interface and could play a critical role in stability. The fre...

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Detalles Bibliográficos
Autores principales: Ihara, Kentaro, Fujiwara, Noriko, Yamaguchi, Yoshiki, Torigoe, Hidetaka, Wakatsuki, Soichi, Taniguchi, Naoyuki, Suzuki, Keiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497728/
https://www.ncbi.nlm.nih.gov/pubmed/22804629
http://dx.doi.org/10.1042/BSR20120029

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