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Advantages and limitations of cell-based assays for GTPase activation and regulation
Small GTPases of the Ras superfamily are important regulators of many cellular functions, including signal transduction, cytoskeleton assembly, metabolic regulation, organelle biogenesis and intracellular transport. Most GTPases act as binary switches, being “on” in the active, GTP-bound state and “...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498073/ https://www.ncbi.nlm.nih.gov/pubmed/23181197 http://dx.doi.org/10.4161/cl.22045 |