EHDs meet the retromer: Complex regulation of retrograde transport

Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tigh...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Naslavsky, Naava, Caplan, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498075/
https://www.ncbi.nlm.nih.gov/pubmed/23181199
http://dx.doi.org/10.4161/cl.20582
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author Zhang, Jing
Naslavsky, Naava
Caplan, Steve
author_facet Zhang, Jing
Naslavsky, Naava
Caplan, Steve
author_sort Zhang, Jing
collection PubMed
description Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. This mini-review focuses on recent findings and discusses the regulation of the retromer complex by EHD proteins and the novel EHD1 interaction partner, Rabankyrin-5 (Rank-5).
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spelling pubmed-34980752012-11-23 EHDs meet the retromer: Complex regulation of retrograde transport Zhang, Jing Naslavsky, Naava Caplan, Steve Cell Logist Review Retrograde trafficking mediates the transport of endocytic membranes from endosomes to the trans-Golgi network (TGN). Dysregulation of these pathways can result in multiple ailments, including late-onset Alzheimer disease. One of the key retrograde transport regulators, the retromer complex, is tightly controlled by many factors, including the C-terminal Eps15 homology domain (EHD) proteins. This mini-review focuses on recent findings and discusses the regulation of the retromer complex by EHD proteins and the novel EHD1 interaction partner, Rabankyrin-5 (Rank-5). Landes Bioscience 2012-07-01 /pmc/articles/PMC3498075/ /pubmed/23181199 http://dx.doi.org/10.4161/cl.20582 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Zhang, Jing
Naslavsky, Naava
Caplan, Steve
EHDs meet the retromer: Complex regulation of retrograde transport
title EHDs meet the retromer: Complex regulation of retrograde transport
title_full EHDs meet the retromer: Complex regulation of retrograde transport
title_fullStr EHDs meet the retromer: Complex regulation of retrograde transport
title_full_unstemmed EHDs meet the retromer: Complex regulation of retrograde transport
title_short EHDs meet the retromer: Complex regulation of retrograde transport
title_sort ehds meet the retromer: complex regulation of retrograde transport
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498075/
https://www.ncbi.nlm.nih.gov/pubmed/23181199
http://dx.doi.org/10.4161/cl.20582
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