Cargando…

The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients

BACKGROUND: The strength of each heart beat and the stiffness of large arteries contribute to blood pressure (BP). When the large arteries are stiff and their resistance greater, the afterload increases and this may change the function of the heart. However, the relation between common carotid arter...

Descripción completa

Detalles Bibliográficos
Autores principales: Myung, Yusik, Seo, Hye-Sun, Jung, In Hyun, Lee, Nae-Hee, Suh, Jon, Choi, Jae Huk, Cho, Yoon Haeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Echocardiography 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498310/
https://www.ncbi.nlm.nih.gov/pubmed/23185656
http://dx.doi.org/10.4250/jcu.2012.20.3.134
_version_ 1782249822785372160
author Myung, Yusik
Seo, Hye-Sun
Jung, In Hyun
Lee, Nae-Hee
Suh, Jon
Choi, Jae Huk
Cho, Yoon Haeng
author_facet Myung, Yusik
Seo, Hye-Sun
Jung, In Hyun
Lee, Nae-Hee
Suh, Jon
Choi, Jae Huk
Cho, Yoon Haeng
author_sort Myung, Yusik
collection PubMed
description BACKGROUND: The strength of each heart beat and the stiffness of large arteries contribute to blood pressure (BP). When the large arteries are stiff and their resistance greater, the afterload increases and this may change the function of the heart. However, the relation between common carotid artery stiffness and heart function in hypertensive patients has not been clarified. METHODS: Two hundred and twenty hypertensive patients underwent transthoracic and carotid echocardiography. Measurements of local arterial stiffness were taken at the right common carotid artery level and stiffness parameter (β), pressure-strain elasticity modulus and intima-media thickness were calculated. Brachial cuff BP was measured just before starting the carotid study. The patients with any cardiovascular disease, diabetes mellitus, stroke, transient ischemic attack, or carotid stenosis were excluded. RESULTS: Carotid artery stiffness parameter (β) was correlated with age and left ventricular mass index (p < 0.005). Even though β was not correlated with LV systolic function, it was inversely correlated with diastolic function as measured by early mitral annular velocity. When the artery was stiffer, early mitral annular velocity (e') decreased (p < 0.001) and the index of left atrial (LA) pressure (early diastolic mitral inflow E velocity/e') increased (p = 0.001). In logistic regression, diastolic dysfunction was affected by age (beta -0.385, p = 0.001), LA volume index (beta 0.175, p = 0.013) and β (beta -0.273, p = 0.019). CONCLUSION: In hypertensive patients, changes in carotid artery stiffness can affect the diastolic function, independent of age and LA volume index. Therefore, measurements and control of carotid stiffness can play an important role in the prevention of diastolic heart failure.
format Online
Article
Text
id pubmed-3498310
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Korean Society of Echocardiography
record_format MEDLINE/PubMed
spelling pubmed-34983102012-11-26 The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients Myung, Yusik Seo, Hye-Sun Jung, In Hyun Lee, Nae-Hee Suh, Jon Choi, Jae Huk Cho, Yoon Haeng J Cardiovasc Ultrasound Original Article BACKGROUND: The strength of each heart beat and the stiffness of large arteries contribute to blood pressure (BP). When the large arteries are stiff and their resistance greater, the afterload increases and this may change the function of the heart. However, the relation between common carotid artery stiffness and heart function in hypertensive patients has not been clarified. METHODS: Two hundred and twenty hypertensive patients underwent transthoracic and carotid echocardiography. Measurements of local arterial stiffness were taken at the right common carotid artery level and stiffness parameter (β), pressure-strain elasticity modulus and intima-media thickness were calculated. Brachial cuff BP was measured just before starting the carotid study. The patients with any cardiovascular disease, diabetes mellitus, stroke, transient ischemic attack, or carotid stenosis were excluded. RESULTS: Carotid artery stiffness parameter (β) was correlated with age and left ventricular mass index (p < 0.005). Even though β was not correlated with LV systolic function, it was inversely correlated with diastolic function as measured by early mitral annular velocity. When the artery was stiffer, early mitral annular velocity (e') decreased (p < 0.001) and the index of left atrial (LA) pressure (early diastolic mitral inflow E velocity/e') increased (p = 0.001). In logistic regression, diastolic dysfunction was affected by age (beta -0.385, p = 0.001), LA volume index (beta 0.175, p = 0.013) and β (beta -0.273, p = 0.019). CONCLUSION: In hypertensive patients, changes in carotid artery stiffness can affect the diastolic function, independent of age and LA volume index. Therefore, measurements and control of carotid stiffness can play an important role in the prevention of diastolic heart failure. Korean Society of Echocardiography 2012-09 2012-09-21 /pmc/articles/PMC3498310/ /pubmed/23185656 http://dx.doi.org/10.4250/jcu.2012.20.3.134 Text en Copyright © 2012 Korean Society of Echocardiography http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Myung, Yusik
Seo, Hye-Sun
Jung, In Hyun
Lee, Nae-Hee
Suh, Jon
Choi, Jae Huk
Cho, Yoon Haeng
The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients
title The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients
title_full The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients
title_fullStr The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients
title_full_unstemmed The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients
title_short The Correlation of Carotid Artery Stiffness with Heart Function in Hypertensive Patients
title_sort correlation of carotid artery stiffness with heart function in hypertensive patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498310/
https://www.ncbi.nlm.nih.gov/pubmed/23185656
http://dx.doi.org/10.4250/jcu.2012.20.3.134
work_keys_str_mv AT myungyusik thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT seohyesun thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT junginhyun thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT leenaehee thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT suhjon thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT choijaehuk thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT choyoonhaeng thecorrelationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT myungyusik correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT seohyesun correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT junginhyun correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT leenaehee correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT suhjon correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT choijaehuk correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients
AT choyoonhaeng correlationofcarotidarterystiffnesswithheartfunctioninhypertensivepatients