Cargando…

A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia

BACKGROUND: Ketorolac is widely used for postoperative analgesia in patients who undergo cesarean delivery. In countries where the use of opioids is considerably restricted, alternatives to narcotics are required. AIM: We hypothesize that the addition of complex B synergize the analgesic effect of k...

Descripción completa

Detalles Bibliográficos
Autores principales: Beltrán-Montoya, J. J., Herrerias-Canedo, T., Arzola-Paniagua, A., Vadillo-Ortega, F., Dueñas-Garcia, Omar Felipe, Rico-Olvera, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498656/
https://www.ncbi.nlm.nih.gov/pubmed/23162391
http://dx.doi.org/10.4103/1658-354X.101209
_version_ 1782249850653376512
author Beltrán-Montoya, J. J.
Herrerias-Canedo, T.
Arzola-Paniagua, A.
Vadillo-Ortega, F.
Dueñas-Garcia, Omar Felipe
Rico-Olvera, H.
author_facet Beltrán-Montoya, J. J.
Herrerias-Canedo, T.
Arzola-Paniagua, A.
Vadillo-Ortega, F.
Dueñas-Garcia, Omar Felipe
Rico-Olvera, H.
author_sort Beltrán-Montoya, J. J.
collection PubMed
description BACKGROUND: Ketorolac is widely used for postoperative analgesia in patients who undergo cesarean delivery. In countries where the use of opioids is considerably restricted, alternatives to narcotics are required. AIM: We hypothesize that the addition of complex B synergize the analgesic effect of ketorolac in postoperative cesarean patients, thus requiring a smaller dose of the anti-inflammatory agent, and therefore decreasing the potential side effects of ketorolac. METHODS: A randomized clinical trial with 100 patients undergoing a primary elective cesarean delivery enrolled in the study. Pain was assessed in the recovery room and then they were randomized to receive ketorolac 30 mg intramuscular (i.m.) or 15 mg of ketorolac plus complex B vitamin (CBV). The pain score with an analog scale was assessed 1, 2, 6, 12, 18, and 24 h after the baseline. The student's t test was performed to compare the demographic differences between the 2 means. RESULTS: 100 patients were included in the study, showing no statistical differences in the demographics. The patient's pain score at 1, 2, 6, 12, 18 and 24 hours showed no statistical differences between the control group (ketorolac 30mg) compared to the group of ketorolac 15mg and complex B vitamins. No changes in the coagulation studies were found in both groups. CONCLUSION: The present study demonstrates that ketorolac 30 mg and ketorolac 15 mg plus complex B vitamins can provide acceptable analgesia in many patients with severe pain.
format Online
Article
Text
id pubmed-3498656
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-34986562012-11-16 A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia Beltrán-Montoya, J. J. Herrerias-Canedo, T. Arzola-Paniagua, A. Vadillo-Ortega, F. Dueñas-Garcia, Omar Felipe Rico-Olvera, H. Saudi J Anaesth Original Article BACKGROUND: Ketorolac is widely used for postoperative analgesia in patients who undergo cesarean delivery. In countries where the use of opioids is considerably restricted, alternatives to narcotics are required. AIM: We hypothesize that the addition of complex B synergize the analgesic effect of ketorolac in postoperative cesarean patients, thus requiring a smaller dose of the anti-inflammatory agent, and therefore decreasing the potential side effects of ketorolac. METHODS: A randomized clinical trial with 100 patients undergoing a primary elective cesarean delivery enrolled in the study. Pain was assessed in the recovery room and then they were randomized to receive ketorolac 30 mg intramuscular (i.m.) or 15 mg of ketorolac plus complex B vitamin (CBV). The pain score with an analog scale was assessed 1, 2, 6, 12, 18, and 24 h after the baseline. The student's t test was performed to compare the demographic differences between the 2 means. RESULTS: 100 patients were included in the study, showing no statistical differences in the demographics. The patient's pain score at 1, 2, 6, 12, 18 and 24 hours showed no statistical differences between the control group (ketorolac 30mg) compared to the group of ketorolac 15mg and complex B vitamins. No changes in the coagulation studies were found in both groups. CONCLUSION: The present study demonstrates that ketorolac 30 mg and ketorolac 15 mg plus complex B vitamins can provide acceptable analgesia in many patients with severe pain. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3498656/ /pubmed/23162391 http://dx.doi.org/10.4103/1658-354X.101209 Text en Copyright: © Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Beltrán-Montoya, J. J.
Herrerias-Canedo, T.
Arzola-Paniagua, A.
Vadillo-Ortega, F.
Dueñas-Garcia, Omar Felipe
Rico-Olvera, H.
A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
title A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
title_full A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
title_fullStr A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
title_full_unstemmed A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
title_short A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
title_sort randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex b vitamins for cesarean delivery analgesia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498656/
https://www.ncbi.nlm.nih.gov/pubmed/23162391
http://dx.doi.org/10.4103/1658-354X.101209
work_keys_str_mv AT beltranmontoyajj arandomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT herreriascanedot arandomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT arzolapaniaguaa arandomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT vadilloortegaf arandomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT duenasgarciaomarfelipe arandomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT ricoolverah arandomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT beltranmontoyajj randomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT herreriascanedot randomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT arzolapaniaguaa randomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT vadilloortegaf randomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT duenasgarciaomarfelipe randomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia
AT ricoolverah randomizedclinicaltrialofketorolactromethaminevsketorolactrometaminepluscomplexbvitaminsforcesareandeliveryanalgesia