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Rubinstein–Taybi Syndrome with Psychosis
Rubinstein–Taybi syndrome (RTS) is a rare genetic disorder with characteristic physical anomalies. It is characterized by mental retardation, postnatal growth deficiency, microcephaly, specific facial characteristics, broad thumbs, and big toes. Behavioral problems are common with RTS; they include...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498786/ https://www.ncbi.nlm.nih.gov/pubmed/23162199 http://dx.doi.org/10.4103/0253-7176.101796 |
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author | Nayak, Raghavendra B. Lakshmappa, Ambika Patil, Nanasaheb M. Chate, Sameeran S. Somashekar, Lohit |
author_facet | Nayak, Raghavendra B. Lakshmappa, Ambika Patil, Nanasaheb M. Chate, Sameeran S. Somashekar, Lohit |
author_sort | Nayak, Raghavendra B. |
collection | PubMed |
description | Rubinstein–Taybi syndrome (RTS) is a rare genetic disorder with characteristic physical anomalies. It is characterized by mental retardation, postnatal growth deficiency, microcephaly, specific facial characteristics, broad thumbs, and big toes. Behavioral problems are common with RTS; they include mental retardation, impulsivity, distractibility, instability of mood, stereotypes, poor coordination, atypical depression, and mania. To date, there is lack of literature on the presence of schizophrenia or non-affective psychosis with RTS. Here, we describe two cases where there is co-morbid psychosis with RTS. One case is diagnosed as paranoid schizophrenia and the other as psychosis possibly schizophrenia. Genetic analysis was not done due to unavailability. The possible etiological factors for the association of psychosis with RTS are discussed. Factors such as regulators of RNA polymerase II and hypoxia-inducible factor 1 alpha (HIF1A) may be some common etiological factors for the association of schizophrenia or non-affective psychosis and RTS. Schizophrenia / non-affective psychosis can be a comorbid psychiatric condition with RTS. |
format | Online Article Text |
id | pubmed-3498786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34987862012-11-16 Rubinstein–Taybi Syndrome with Psychosis Nayak, Raghavendra B. Lakshmappa, Ambika Patil, Nanasaheb M. Chate, Sameeran S. Somashekar, Lohit Indian J Psychol Med Case Report Rubinstein–Taybi syndrome (RTS) is a rare genetic disorder with characteristic physical anomalies. It is characterized by mental retardation, postnatal growth deficiency, microcephaly, specific facial characteristics, broad thumbs, and big toes. Behavioral problems are common with RTS; they include mental retardation, impulsivity, distractibility, instability of mood, stereotypes, poor coordination, atypical depression, and mania. To date, there is lack of literature on the presence of schizophrenia or non-affective psychosis with RTS. Here, we describe two cases where there is co-morbid psychosis with RTS. One case is diagnosed as paranoid schizophrenia and the other as psychosis possibly schizophrenia. Genetic analysis was not done due to unavailability. The possible etiological factors for the association of psychosis with RTS are discussed. Factors such as regulators of RNA polymerase II and hypoxia-inducible factor 1 alpha (HIF1A) may be some common etiological factors for the association of schizophrenia or non-affective psychosis and RTS. Schizophrenia / non-affective psychosis can be a comorbid psychiatric condition with RTS. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3498786/ /pubmed/23162199 http://dx.doi.org/10.4103/0253-7176.101796 Text en Copyright: © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nayak, Raghavendra B. Lakshmappa, Ambika Patil, Nanasaheb M. Chate, Sameeran S. Somashekar, Lohit Rubinstein–Taybi Syndrome with Psychosis |
title | Rubinstein–Taybi Syndrome with Psychosis |
title_full | Rubinstein–Taybi Syndrome with Psychosis |
title_fullStr | Rubinstein–Taybi Syndrome with Psychosis |
title_full_unstemmed | Rubinstein–Taybi Syndrome with Psychosis |
title_short | Rubinstein–Taybi Syndrome with Psychosis |
title_sort | rubinstein–taybi syndrome with psychosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498786/ https://www.ncbi.nlm.nih.gov/pubmed/23162199 http://dx.doi.org/10.4103/0253-7176.101796 |
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