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Mechanistic and structural basis for inhibition of thymidylate synthase ThyX

Nature has established two mechanistically and structurally unrelated families of thymidylate synthases that produce de novo thymidylate or dTMP, an essential DNA precursor. Representatives of the alternative flavin-dependent thymidylate synthase family, ThyX, are found in a large number of microbia...

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Detalles Bibliográficos
Autores principales:	Basta, Tamara, Boum, Yap, Briffotaux, Julien, Becker, Hubert F., Lamarre-Jouenne, Isabelle, Lambry, Jean-Christophe, Skouloubris, Stephane, Liebl, Ursula, Graille, Marc, van Tilbeurgh, Herman, Myllykallio, Hannu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498832/ https://www.ncbi.nlm.nih.gov/pubmed/23155486 http://dx.doi.org/10.1098/rsob.120120

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