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TLR8: the forgotten relative revindicated
The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially thought to be non-functional in mice, less is known about TLR8 than the genetically and functionally related TLR7. Originally associ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498840/ https://www.ncbi.nlm.nih.gov/pubmed/23085951 http://dx.doi.org/10.1038/cmi.2012.38 |
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author | Cervantes, Jorge L Weinerman, Bennett Basole, Chaitali Salazar, Juan C |
author_facet | Cervantes, Jorge L Weinerman, Bennett Basole, Chaitali Salazar, Juan C |
author_sort | Cervantes, Jorge L |
collection | PubMed |
description | The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially thought to be non-functional in mice, less is known about TLR8 than the genetically and functionally related TLR7. Originally associated with the recognition of single-stranded RNA of viral origin, there is now evidence that human TLR8 is also able to sense bacterial RNA released within phagosomal vacuoles, inducing the production of both nuclear factor (NF)-κB-dependent cytokines and type I interferons (IFNs), such as IFN-β. The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity. |
format | Online Article Text |
id | pubmed-3498840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34988402012-11-15 TLR8: the forgotten relative revindicated Cervantes, Jorge L Weinerman, Bennett Basole, Chaitali Salazar, Juan C Cell Mol Immunol Mini Review The endosomal Toll-like receptors (TLRs) TLR3, TLR7, TLR8 and TLR9 are important in sensing foreign nucleic acids encountered by phagocytes. Because TLR8 was initially thought to be non-functional in mice, less is known about TLR8 than the genetically and functionally related TLR7. Originally associated with the recognition of single-stranded RNA of viral origin, there is now evidence that human TLR8 is also able to sense bacterial RNA released within phagosomal vacuoles, inducing the production of both nuclear factor (NF)-κB-dependent cytokines and type I interferons (IFNs), such as IFN-β. The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity. Nature Publishing Group 2012-11 2012-10-22 /pmc/articles/PMC3498840/ /pubmed/23085951 http://dx.doi.org/10.1038/cmi.2012.38 Text en Copyright © 2012 Chinese Society of Immunology and The University of Science and Technology http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0 |
spellingShingle | Mini Review Cervantes, Jorge L Weinerman, Bennett Basole, Chaitali Salazar, Juan C TLR8: the forgotten relative revindicated |
title | TLR8: the forgotten relative revindicated |
title_full | TLR8: the forgotten relative revindicated |
title_fullStr | TLR8: the forgotten relative revindicated |
title_full_unstemmed | TLR8: the forgotten relative revindicated |
title_short | TLR8: the forgotten relative revindicated |
title_sort | tlr8: the forgotten relative revindicated |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498840/ https://www.ncbi.nlm.nih.gov/pubmed/23085951 http://dx.doi.org/10.1038/cmi.2012.38 |
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