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Changes in intraocular pressure after pharmacologic pupil dilation

BACKGROUND: Intraocular pressure (IOP) may vary according to the change of ocular conditions. In this study, we want to assess the effect and mechanism of pupil dilation on IOP in normal subjects. METHODS: We prospectively evaluated 32 eyes of 32 patients (age; 61.7 ± 8.2 years) with normal open ang...

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Autores principales: Kim, Joon Mo, Park, Ki Ho, Han, So Young, Kim, Kwan Soo, Kim, Dong Myung, Kim, Tae Woo, Caprioli, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499138/
https://www.ncbi.nlm.nih.gov/pubmed/23017184
http://dx.doi.org/10.1186/1471-2415-12-53
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author Kim, Joon Mo
Park, Ki Ho
Han, So Young
Kim, Kwan Soo
Kim, Dong Myung
Kim, Tae Woo
Caprioli, Joseph
author_facet Kim, Joon Mo
Park, Ki Ho
Han, So Young
Kim, Kwan Soo
Kim, Dong Myung
Kim, Tae Woo
Caprioli, Joseph
author_sort Kim, Joon Mo
collection PubMed
description BACKGROUND: Intraocular pressure (IOP) may vary according to the change of ocular conditions. In this study, we want to assess the effect and mechanism of pupil dilation on IOP in normal subjects. METHODS: We prospectively evaluated 32 eyes of 32 patients (age; 61.7 ± 8.2 years) with normal open angles under diurnal IOP. IOP was measured every two hours from 9 AM to 11 PM for one day to establish baseline values and was measured again for one day to assess the differences after dilation. To induce dilation, we administered 2.5% phenylephrine and 1% tropicamide every 5 minutes from 8:30 AM to 8:45 AM and for every two hours from 11 AM to 9 PM to keep the pupil dilated. Diurnal IOP, biometry, Visante OCT, and laser flare photometry were measured before and after dilation. RESULTS: We observed a significant increase in IOP after dilation, 1.85 ± 2.01 mmHg (p = 0.002). IOP elevation remained significant until about four hours after dilation. Thereafter, IOP decreased slowly and eventually reached pre-dilation level (p > 0.05). Flare values decreased, and the anterior chamber angle became wider after mydriasis. CONCLUSIONS: Dilation of the pupil significantly and incidentally elevated IOP in normal subjects. Further related studies are warranted to characterize the mechanism of the increased IOP after dilation.
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spelling pubmed-34991382012-11-16 Changes in intraocular pressure after pharmacologic pupil dilation Kim, Joon Mo Park, Ki Ho Han, So Young Kim, Kwan Soo Kim, Dong Myung Kim, Tae Woo Caprioli, Joseph BMC Ophthalmol Research Article BACKGROUND: Intraocular pressure (IOP) may vary according to the change of ocular conditions. In this study, we want to assess the effect and mechanism of pupil dilation on IOP in normal subjects. METHODS: We prospectively evaluated 32 eyes of 32 patients (age; 61.7 ± 8.2 years) with normal open angles under diurnal IOP. IOP was measured every two hours from 9 AM to 11 PM for one day to establish baseline values and was measured again for one day to assess the differences after dilation. To induce dilation, we administered 2.5% phenylephrine and 1% tropicamide every 5 minutes from 8:30 AM to 8:45 AM and for every two hours from 11 AM to 9 PM to keep the pupil dilated. Diurnal IOP, biometry, Visante OCT, and laser flare photometry were measured before and after dilation. RESULTS: We observed a significant increase in IOP after dilation, 1.85 ± 2.01 mmHg (p = 0.002). IOP elevation remained significant until about four hours after dilation. Thereafter, IOP decreased slowly and eventually reached pre-dilation level (p > 0.05). Flare values decreased, and the anterior chamber angle became wider after mydriasis. CONCLUSIONS: Dilation of the pupil significantly and incidentally elevated IOP in normal subjects. Further related studies are warranted to characterize the mechanism of the increased IOP after dilation. BioMed Central 2012-09-27 /pmc/articles/PMC3499138/ /pubmed/23017184 http://dx.doi.org/10.1186/1471-2415-12-53 Text en Copyright ©2012 Kim et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kim, Joon Mo
Park, Ki Ho
Han, So Young
Kim, Kwan Soo
Kim, Dong Myung
Kim, Tae Woo
Caprioli, Joseph
Changes in intraocular pressure after pharmacologic pupil dilation
title Changes in intraocular pressure after pharmacologic pupil dilation
title_full Changes in intraocular pressure after pharmacologic pupil dilation
title_fullStr Changes in intraocular pressure after pharmacologic pupil dilation
title_full_unstemmed Changes in intraocular pressure after pharmacologic pupil dilation
title_short Changes in intraocular pressure after pharmacologic pupil dilation
title_sort changes in intraocular pressure after pharmacologic pupil dilation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499138/
https://www.ncbi.nlm.nih.gov/pubmed/23017184
http://dx.doi.org/10.1186/1471-2415-12-53
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