Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer

BACKGROUND: Successful treatment of solid tumors relies on the ability of drugs to penetrate into the tumor tissue. METHODS: We examined the correlation of panitumumab (an anti-epidermal growth factor [EGFR] antibody) tumor penetration and EGFR saturation, a potential obstacle in large molecule drug...

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Detalles Bibliográficos
Autores principales: Freeman, Daniel J, McDorman, Kevin, Ogbagabriel, Selam, Kozlosky, Carl, Yang, Bing-Bing, Doshi, Sameer, Perez-Ruxio, Juan Jose, Fanslow, William, Starnes, Charlie, Radinsky, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499177/
https://www.ncbi.nlm.nih.gov/pubmed/22830443
http://dx.doi.org/10.1186/1476-4598-11-47

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