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Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols

BACKGROUND: Over the past decade, advances in cancer treatments have been counterbalanced by a rising number of immunosuppressed patients with a multitude of new risk factors for infection. Hence, the aim of this study was to determine risk factors, infectious pathogens in blood and oral cavity of o...

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Autores principales: Panghal, Manju, Kaushal, Vivek, Kadayan, Sangeeta, Yadav, Jaya Parkash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499184/
https://www.ncbi.nlm.nih.gov/pubmed/22817766
http://dx.doi.org/10.1186/1472-6831-12-22
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author Panghal, Manju
Kaushal, Vivek
Kadayan, Sangeeta
Yadav, Jaya Parkash
author_facet Panghal, Manju
Kaushal, Vivek
Kadayan, Sangeeta
Yadav, Jaya Parkash
author_sort Panghal, Manju
collection PubMed
description BACKGROUND: Over the past decade, advances in cancer treatments have been counterbalanced by a rising number of immunosuppressed patients with a multitude of new risk factors for infection. Hence, the aim of this study was to determine risk factors, infectious pathogens in blood and oral cavity of oral cancer patients undergoing different treatment procedures. METHODS: The present prospective cohort analysis was conducted on the patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, during the period of January 2007 to October 2009. Total 186 patients with squamous cell carcinoma of oral cavity were analyzed in the study. Based on treatment procedures patients were divided into three groups, group I were under radiotherapy, group II under chemotherapy and group III were of radio chemotherapy together. Clinical isolates from blood and oral cavity were identified by following general microbiological, staining and biochemical methods. The absolute neutrophile counts were done by following the standard methods. RESULTS: Prevalent bacterial pathogens isolated were Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Proteus vulgaris and the fungal pathogens were Candida albicans, Aspergillus fumigatus. The predominant gram negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumonia were isolated from blood of radiotherapy and oral cavity of chemotherapy treated cases respectively. The predominance of gram positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis) were observed in blood of chemotherapy, radio chemotherapy cases and oral cavity of radiotherapy, radio chemotherapy treated cases. Our study also revealed the presence of C. albicans fungi as most significant oral cavity pathogens in radiotherapy and radio chemotherapy cases. CONCLUSION: Gram positive bacteria and Gram negative were reported from the blood of all the three groups of patients. Oral mucositis played a significant role in oral cavity infection and make patients more prone to C. albicans infection.
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spelling pubmed-34991842012-11-20 Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols Panghal, Manju Kaushal, Vivek Kadayan, Sangeeta Yadav, Jaya Parkash BMC Oral Health Research Article BACKGROUND: Over the past decade, advances in cancer treatments have been counterbalanced by a rising number of immunosuppressed patients with a multitude of new risk factors for infection. Hence, the aim of this study was to determine risk factors, infectious pathogens in blood and oral cavity of oral cancer patients undergoing different treatment procedures. METHODS: The present prospective cohort analysis was conducted on the patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, during the period of January 2007 to October 2009. Total 186 patients with squamous cell carcinoma of oral cavity were analyzed in the study. Based on treatment procedures patients were divided into three groups, group I were under radiotherapy, group II under chemotherapy and group III were of radio chemotherapy together. Clinical isolates from blood and oral cavity were identified by following general microbiological, staining and biochemical methods. The absolute neutrophile counts were done by following the standard methods. RESULTS: Prevalent bacterial pathogens isolated were Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Proteus vulgaris and the fungal pathogens were Candida albicans, Aspergillus fumigatus. The predominant gram negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumonia were isolated from blood of radiotherapy and oral cavity of chemotherapy treated cases respectively. The predominance of gram positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis) were observed in blood of chemotherapy, radio chemotherapy cases and oral cavity of radiotherapy, radio chemotherapy treated cases. Our study also revealed the presence of C. albicans fungi as most significant oral cavity pathogens in radiotherapy and radio chemotherapy cases. CONCLUSION: Gram positive bacteria and Gram negative were reported from the blood of all the three groups of patients. Oral mucositis played a significant role in oral cavity infection and make patients more prone to C. albicans infection. BioMed Central 2012-07-20 /pmc/articles/PMC3499184/ /pubmed/22817766 http://dx.doi.org/10.1186/1472-6831-12-22 Text en Copyright ©2012 Panghal et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Panghal, Manju
Kaushal, Vivek
Kadayan, Sangeeta
Yadav, Jaya Parkash
Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
title Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
title_full Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
title_fullStr Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
title_full_unstemmed Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
title_short Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
title_sort incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499184/
https://www.ncbi.nlm.nih.gov/pubmed/22817766
http://dx.doi.org/10.1186/1472-6831-12-22
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