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The Dominant Folding Route Minimizes Backbone Distortion in SH3
Energetic frustration in protein folding is minimized by evolution to create a smooth and robust energy landscape. As a result the geometry of the native structure provides key constraints that shape protein folding mechanisms. Chain connectivity in particular has been identified as an essential com...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499259/ https://www.ncbi.nlm.nih.gov/pubmed/23166485 http://dx.doi.org/10.1371/journal.pcbi.1002776 |