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Major postoperative complications and survival for colon cancer elderly patients
BACKGROUND: Increased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated. METHODS: We retrospectively analysed a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499273/ https://www.ncbi.nlm.nih.gov/pubmed/23173563 http://dx.doi.org/10.1186/1471-2482-12-S1-S20 |
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author | Grosso, Giuseppe Biondi, Antonio Marventano, Stefano Mistretta, Antonio Calabrese, Giorgio Basile, Francesco |
author_facet | Grosso, Giuseppe Biondi, Antonio Marventano, Stefano Mistretta, Antonio Calabrese, Giorgio Basile, Francesco |
author_sort | Grosso, Giuseppe |
collection | PubMed |
description | BACKGROUND: Increased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated. METHODS: We retrospectively analysed a database containing the information of patients who underwent surgery for stage I-III colorectal cancer from January 2004 to January 2012 at our institution and compared demographic, cancer-related, and outcomes data of 235 elderly patients with 211 patients ≤65 years old. RESULTS: Intraoperative complications did not differ between young and old patients whereas some differences have been found in postoperative and late complications: elderly patients suffered more by ileus (P = 0.024), peritonitis or septic shock (P = 0.017), pelvic abscess (P = 0.028), wound infection (P = 0.031), and incisional/port herniation (P = 0.012) compared with younger patients. Moreover, elderly patients suffered by systemic complications such as cardiovascular (4.7% vs. 1.4%, P = 0.049), renal (4.7% vs. 0.5%, P = 0.006), and respiratory (10.6% vs. 5.2%, P = 0.036). The multivariate analysis assessing the odds of having a complication revealed that older age (Odd Ratio [OR] 2.75, 95% Confidential Interval [CI]: 1.67-4.52) and open surgery (OR 1.63, 95% CI: 1.01-2.62) are significantly and independently associated with having a complication. CONCLUSIONS: In our series, elderly patients have presented a slight higher incidence of comorbidities that may affect the incidence rates of postoperative complications. These results have implications in increasing the hospital stay as well as a higher rate of death. |
format | Online Article Text |
id | pubmed-3499273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34992732012-11-20 Major postoperative complications and survival for colon cancer elderly patients Grosso, Giuseppe Biondi, Antonio Marventano, Stefano Mistretta, Antonio Calabrese, Giorgio Basile, Francesco BMC Surg Research Article BACKGROUND: Increased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated. METHODS: We retrospectively analysed a database containing the information of patients who underwent surgery for stage I-III colorectal cancer from January 2004 to January 2012 at our institution and compared demographic, cancer-related, and outcomes data of 235 elderly patients with 211 patients ≤65 years old. RESULTS: Intraoperative complications did not differ between young and old patients whereas some differences have been found in postoperative and late complications: elderly patients suffered more by ileus (P = 0.024), peritonitis or septic shock (P = 0.017), pelvic abscess (P = 0.028), wound infection (P = 0.031), and incisional/port herniation (P = 0.012) compared with younger patients. Moreover, elderly patients suffered by systemic complications such as cardiovascular (4.7% vs. 1.4%, P = 0.049), renal (4.7% vs. 0.5%, P = 0.006), and respiratory (10.6% vs. 5.2%, P = 0.036). The multivariate analysis assessing the odds of having a complication revealed that older age (Odd Ratio [OR] 2.75, 95% Confidential Interval [CI]: 1.67-4.52) and open surgery (OR 1.63, 95% CI: 1.01-2.62) are significantly and independently associated with having a complication. CONCLUSIONS: In our series, elderly patients have presented a slight higher incidence of comorbidities that may affect the incidence rates of postoperative complications. These results have implications in increasing the hospital stay as well as a higher rate of death. BioMed Central 2012-11-15 /pmc/articles/PMC3499273/ /pubmed/23173563 http://dx.doi.org/10.1186/1471-2482-12-S1-S20 Text en Copyright ©2012 Grosso et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Grosso, Giuseppe Biondi, Antonio Marventano, Stefano Mistretta, Antonio Calabrese, Giorgio Basile, Francesco Major postoperative complications and survival for colon cancer elderly patients |
title | Major postoperative complications and survival for colon cancer elderly patients |
title_full | Major postoperative complications and survival for colon cancer elderly patients |
title_fullStr | Major postoperative complications and survival for colon cancer elderly patients |
title_full_unstemmed | Major postoperative complications and survival for colon cancer elderly patients |
title_short | Major postoperative complications and survival for colon cancer elderly patients |
title_sort | major postoperative complications and survival for colon cancer elderly patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499273/ https://www.ncbi.nlm.nih.gov/pubmed/23173563 http://dx.doi.org/10.1186/1471-2482-12-S1-S20 |
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