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Major postoperative complications and survival for colon cancer elderly patients

BACKGROUND: Increased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated. METHODS: We retrospectively analysed a...

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Autores principales: Grosso, Giuseppe, Biondi, Antonio, Marventano, Stefano, Mistretta, Antonio, Calabrese, Giorgio, Basile, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499273/
https://www.ncbi.nlm.nih.gov/pubmed/23173563
http://dx.doi.org/10.1186/1471-2482-12-S1-S20
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author Grosso, Giuseppe
Biondi, Antonio
Marventano, Stefano
Mistretta, Antonio
Calabrese, Giorgio
Basile, Francesco
author_facet Grosso, Giuseppe
Biondi, Antonio
Marventano, Stefano
Mistretta, Antonio
Calabrese, Giorgio
Basile, Francesco
author_sort Grosso, Giuseppe
collection PubMed
description BACKGROUND: Increased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated. METHODS: We retrospectively analysed a database containing the information of patients who underwent surgery for stage I-III colorectal cancer from January 2004 to January 2012 at our institution and compared demographic, cancer-related, and outcomes data of 235 elderly patients with 211 patients ≤65 years old. RESULTS: Intraoperative complications did not differ between young and old patients whereas some differences have been found in postoperative and late complications: elderly patients suffered more by ileus (P = 0.024), peritonitis or septic shock (P = 0.017), pelvic abscess (P = 0.028), wound infection (P = 0.031), and incisional/port herniation (P = 0.012) compared with younger patients. Moreover, elderly patients suffered by systemic complications such as cardiovascular (4.7% vs. 1.4%, P = 0.049), renal (4.7% vs. 0.5%, P = 0.006), and respiratory (10.6% vs. 5.2%, P = 0.036). The multivariate analysis assessing the odds of having a complication revealed that older age (Odd Ratio [OR] 2.75, 95% Confidential Interval [CI]: 1.67-4.52) and open surgery (OR 1.63, 95% CI: 1.01-2.62) are significantly and independently associated with having a complication. CONCLUSIONS: In our series, elderly patients have presented a slight higher incidence of comorbidities that may affect the incidence rates of postoperative complications. These results have implications in increasing the hospital stay as well as a higher rate of death.
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spelling pubmed-34992732012-11-20 Major postoperative complications and survival for colon cancer elderly patients Grosso, Giuseppe Biondi, Antonio Marventano, Stefano Mistretta, Antonio Calabrese, Giorgio Basile, Francesco BMC Surg Research Article BACKGROUND: Increased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated. METHODS: We retrospectively analysed a database containing the information of patients who underwent surgery for stage I-III colorectal cancer from January 2004 to January 2012 at our institution and compared demographic, cancer-related, and outcomes data of 235 elderly patients with 211 patients ≤65 years old. RESULTS: Intraoperative complications did not differ between young and old patients whereas some differences have been found in postoperative and late complications: elderly patients suffered more by ileus (P = 0.024), peritonitis or septic shock (P = 0.017), pelvic abscess (P = 0.028), wound infection (P = 0.031), and incisional/port herniation (P = 0.012) compared with younger patients. Moreover, elderly patients suffered by systemic complications such as cardiovascular (4.7% vs. 1.4%, P = 0.049), renal (4.7% vs. 0.5%, P = 0.006), and respiratory (10.6% vs. 5.2%, P = 0.036). The multivariate analysis assessing the odds of having a complication revealed that older age (Odd Ratio [OR] 2.75, 95% Confidential Interval [CI]: 1.67-4.52) and open surgery (OR 1.63, 95% CI: 1.01-2.62) are significantly and independently associated with having a complication. CONCLUSIONS: In our series, elderly patients have presented a slight higher incidence of comorbidities that may affect the incidence rates of postoperative complications. These results have implications in increasing the hospital stay as well as a higher rate of death. BioMed Central 2012-11-15 /pmc/articles/PMC3499273/ /pubmed/23173563 http://dx.doi.org/10.1186/1471-2482-12-S1-S20 Text en Copyright ©2012 Grosso et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grosso, Giuseppe
Biondi, Antonio
Marventano, Stefano
Mistretta, Antonio
Calabrese, Giorgio
Basile, Francesco
Major postoperative complications and survival for colon cancer elderly patients
title Major postoperative complications and survival for colon cancer elderly patients
title_full Major postoperative complications and survival for colon cancer elderly patients
title_fullStr Major postoperative complications and survival for colon cancer elderly patients
title_full_unstemmed Major postoperative complications and survival for colon cancer elderly patients
title_short Major postoperative complications and survival for colon cancer elderly patients
title_sort major postoperative complications and survival for colon cancer elderly patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499273/
https://www.ncbi.nlm.nih.gov/pubmed/23173563
http://dx.doi.org/10.1186/1471-2482-12-S1-S20
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