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Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
Despite the clinical success of anti-tumor necrosis factor (TNF) therapies in the treatment of inflammatory conditions such as rheumatoid arthritis, Crohn disease and psoriasis, full control of the diseases only occurs in a subset of patients and there is a need for new therapeutics with improved ef...
Autores principales: | Kanakaraj, Palanisamy, Puffer, Bridget A., Yao, Xiao-Tao, Kankanala, Spandana, Boyd, Ernest, Shah, Rutul R., Wang, Geping, Patel, Dimki, Krishnamurthy, Rajesh, Kaithamana, Shashi, Smith, Rodger G., LaFleur, David W., Barbas III, Carlos F., Hilbert, David M., Kiener, Peter A., Roschke, Viktor V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499301/ https://www.ncbi.nlm.nih.gov/pubmed/22864384 http://dx.doi.org/10.4161/mabs.21227 |
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