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Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

Most proteins are regulated by physical interactions with other molecules; some are highly specific, but others interact with many partners. Despite much speculation, we know little about how and why specificity/promiscuity evolves in natural proteins. It is widely assumed that specific proteins evo...

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Detalles Bibliográficos
Autores principales: Eick, Geeta N., Colucci, Jennifer K., Harms, Michael J., Ortlund, Eric A., Thornton, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499368/
https://www.ncbi.nlm.nih.gov/pubmed/23166518
http://dx.doi.org/10.1371/journal.pgen.1003072