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Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors
Most proteins are regulated by physical interactions with other molecules; some are highly specific, but others interact with many partners. Despite much speculation, we know little about how and why specificity/promiscuity evolves in natural proteins. It is widely assumed that specific proteins evo...
Autores principales: | Eick, Geeta N., Colucci, Jennifer K., Harms, Michael J., Ortlund, Eric A., Thornton, Joseph W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499368/ https://www.ncbi.nlm.nih.gov/pubmed/23166518 http://dx.doi.org/10.1371/journal.pgen.1003072 |
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