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RNA Splicing Is Responsive to MBNL1 Dose

Myotonic dystrophy (DM1) is a highly variable, multi-system disorder resulting from the expansion of an untranslated CTG tract in DMPK. In DM1 expanded CUG repeat RNAs form hairpin secondary structures that bind and aberrantly sequester the RNA splice regulator, MBNL1. RNA splice defects resulting a...

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Detalles Bibliográficos
Autores principales:	Jog, Sonali P., Paul, Sharan, Dansithong, Warunee, Tring, Stephanie, Comai, Lucio, Reddy, Sita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499511/ https://www.ncbi.nlm.nih.gov/pubmed/23166594 http://dx.doi.org/10.1371/journal.pone.0048825

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