Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stre...

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Detalles Bibliográficos
Autores principales: Suh, Dong Hoon, Kim, Mi-Kyung, Kim, Hee Seung, Chung, Hyun Hoon, Song, Yong Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499662/
https://www.ncbi.nlm.nih.gov/pubmed/23050960
http://dx.doi.org/10.1111/j.1749-6632.2012.06739.x

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