Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

Gymnosis is the process of the delivery of antisense oligodeoxynucleotides to cells, in the absence of any carriers or conjugation, that produces sequence-specific gene silencing. While gymnosis was originally demonstrated using locked nucleic acid (LNA) gapmers, 2′-deoxy-2′fluoroarabino nucleic aci...

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Detalles Bibliográficos
Autores principales: Souleimanian, Naira, Deleavey, Glen F, Soifer, Harris, Wang, Sijian, Tiemann, Katrin, Damha, Masad J, Stein, Cy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499694/
https://www.ncbi.nlm.nih.gov/pubmed/23344235
http://dx.doi.org/10.1038/mtna.2012.35

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