Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses

The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recogniti...

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Autores principales: van de Sandt, Carolien E., Kreijtz, Joost H. C. M., Rimmelzwaan, Guus F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499814/
https://www.ncbi.nlm.nih.gov/pubmed/23170167
http://dx.doi.org/10.3390/v4091438
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author van de Sandt, Carolien E.
Kreijtz, Joost H. C. M.
Rimmelzwaan, Guus F.
author_facet van de Sandt, Carolien E.
Kreijtz, Joost H. C. M.
Rimmelzwaan, Guus F.
author_sort van de Sandt, Carolien E.
collection PubMed
description The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
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spelling pubmed-34998142012-11-20 Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses van de Sandt, Carolien E. Kreijtz, Joost H. C. M. Rimmelzwaan, Guus F. Viruses Review The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies. MDPI 2012-09-03 /pmc/articles/PMC3499814/ /pubmed/23170167 http://dx.doi.org/10.3390/v4091438 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
van de Sandt, Carolien E.
Kreijtz, Joost H. C. M.
Rimmelzwaan, Guus F.
Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
title Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
title_full Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
title_fullStr Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
title_full_unstemmed Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
title_short Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
title_sort evasion of influenza a viruses from innate and adaptive immune responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499814/
https://www.ncbi.nlm.nih.gov/pubmed/23170167
http://dx.doi.org/10.3390/v4091438
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