Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?

Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of...

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Detalles Bibliográficos
Autores principales: James, Stephanie F., Mahalingam, Ravi, Gilden, Don
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499816/
https://www.ncbi.nlm.nih.gov/pubmed/23170169
http://dx.doi.org/10.3390/v4091509
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author James, Stephanie F.
Mahalingam, Ravi
Gilden, Don
author_facet James, Stephanie F.
Mahalingam, Ravi
Gilden, Don
author_sort James, Stephanie F.
collection PubMed
description Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV.
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spelling pubmed-34998162012-11-20 Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation? James, Stephanie F. Mahalingam, Ravi Gilden, Don Viruses Review Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non‑neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV. MDPI 2012-09-11 /pmc/articles/PMC3499816/ /pubmed/23170169 http://dx.doi.org/10.3390/v4091509 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
James, Stephanie F.
Mahalingam, Ravi
Gilden, Don
Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
title Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
title_full Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
title_fullStr Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
title_full_unstemmed Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
title_short Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
title_sort does apoptosis play a role in varicella zoster virus latency and reactivation?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499816/
https://www.ncbi.nlm.nih.gov/pubmed/23170169
http://dx.doi.org/10.3390/v4091509
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