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Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD
BACKGROUND/AIM: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent cause of chronic liver disease worldwide. A number of these patients progress to nonalcoholic steatohepatitis (NASH) which carries significant morbidity and mortality. The aim of this study is to evaluate the diag...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500022/ https://www.ncbi.nlm.nih.gov/pubmed/23006461 http://dx.doi.org/10.4103/1319-3767.101132 |
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author | Mahmoud, Adel A. Bakir, Amal S. Shabana, Sherif S. |
author_facet | Mahmoud, Adel A. Bakir, Amal S. Shabana, Sherif S. |
author_sort | Mahmoud, Adel A. |
collection | PubMed |
description | BACKGROUND/AIM: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent cause of chronic liver disease worldwide. A number of these patients progress to nonalcoholic steatohepatitis (NASH) which carries significant morbidity and mortality. The aim of this study is to evaluate the diagnostic value of serum levels of transforming growth factor beta-1 (TGF-β1) matrix metalloproteinase-1 (MMP-1), and insulin resistance as predictors of fibrosis in Egyptian NAFLD patients. PATIENTS AND METHODS: Fifty patients with NAFLD and different stages of fibrosis were studied. Serum levels of TGF-β1, MMP-1, and fasting serum insulin were measured; calculation of the homeostasis model assessment for insulin resistance (HOMA-IR) was done. RESULTS: TGF-β1 gives a sensitivity of 100% and specificity of 94.4% for stage 1 fibrosis, 100% and 93.9%, respectively, for stage 2 fibrosis, and 97.7% and 100%, respectively, for stage 3 fibrosis. MMP-1 showed sensitivity and specificity of 88% and 81.8%, respectively, for stage 2 fibrosis, 90.9% and 55.56%, respectively, for stage 3 fibrosis, but it is of no diagnostic value in stage 1 fibrosis. CONCLUSION: Serum TGF-β1, MMP-1, and insulin resistance (HOMA-IR) proved to be potentially useful noninvasive markers in predicting fibrosis in NASH patients. |
format | Online Article Text |
id | pubmed-3500022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35000222012-11-23 Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD Mahmoud, Adel A. Bakir, Amal S. Shabana, Sherif S. Saudi J Gastroenterol Original Article BACKGROUND/AIM: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent cause of chronic liver disease worldwide. A number of these patients progress to nonalcoholic steatohepatitis (NASH) which carries significant morbidity and mortality. The aim of this study is to evaluate the diagnostic value of serum levels of transforming growth factor beta-1 (TGF-β1) matrix metalloproteinase-1 (MMP-1), and insulin resistance as predictors of fibrosis in Egyptian NAFLD patients. PATIENTS AND METHODS: Fifty patients with NAFLD and different stages of fibrosis were studied. Serum levels of TGF-β1, MMP-1, and fasting serum insulin were measured; calculation of the homeostasis model assessment for insulin resistance (HOMA-IR) was done. RESULTS: TGF-β1 gives a sensitivity of 100% and specificity of 94.4% for stage 1 fibrosis, 100% and 93.9%, respectively, for stage 2 fibrosis, and 97.7% and 100%, respectively, for stage 3 fibrosis. MMP-1 showed sensitivity and specificity of 88% and 81.8%, respectively, for stage 2 fibrosis, 90.9% and 55.56%, respectively, for stage 3 fibrosis, but it is of no diagnostic value in stage 1 fibrosis. CONCLUSION: Serum TGF-β1, MMP-1, and insulin resistance (HOMA-IR) proved to be potentially useful noninvasive markers in predicting fibrosis in NASH patients. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3500022/ /pubmed/23006461 http://dx.doi.org/10.4103/1319-3767.101132 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mahmoud, Adel A. Bakir, Amal S. Shabana, Sherif S. Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD |
title | Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD |
title_full | Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD |
title_fullStr | Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD |
title_full_unstemmed | Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD |
title_short | Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD |
title_sort | serum tgf-β, serum mmp-1, and homa-ir as non-invasive predictors of fibrosis in egyptian patients with nafld |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500022/ https://www.ncbi.nlm.nih.gov/pubmed/23006461 http://dx.doi.org/10.4103/1319-3767.101132 |
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