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Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

BACKGROUND: The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antiba...

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Autores principales: Yu, Deng-Guang, Zhou, Jie, Chatterton, Nicholas P, Li, Ying, Huang, Jing, Wang, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500032/
https://www.ncbi.nlm.nih.gov/pubmed/23166437
http://dx.doi.org/10.2147/IJN.S37455
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author Yu, Deng-Guang
Zhou, Jie
Chatterton, Nicholas P
Li, Ying
Huang, Jing
Wang, Xia
author_facet Yu, Deng-Guang
Zhou, Jie
Chatterton, Nicholas P
Li, Ying
Huang, Jing
Wang, Xia
author_sort Yu, Deng-Guang
collection PubMed
description BACKGROUND: The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antibacterial effect of Ag can be improved substantially. METHODS: Using polyacrylonitrile (PAN) as the filament-forming polymer matrix, an electrospinnable PAN solution was prepared as the core fluid. A silver nitrate (AgNO(3)) solution was exploited as sheath fluid to carry out the modified coaxial electrospinning process under varied sheath-to-core flow rate ratios. RESULTS: Scanning electron microscopy and transmission electron microscopy demonstrated that the sheath AgNO(3) solution can take a role in reducing the nanofibers’ diameters significantly, a sheath-to-core flow rate ratio of 0.1 and 0.2 resulting in PAN nanofibers with diameters of 380 ± 110 nm and 230 ± 70 nm respectively. AgNPs are well distributed on the surface of PAN nanofibers. The antibacterial experiments demonstrated that these nanofibers show strong antimicrobial activities against Bacillus subtilis Wb800, and Escherichia coli dh5α. CONCLUSION: Coaxial electrospinning with AgNO(3) solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. We report an example of the systematic design, preparation, and application of a novel type of antibacterial material coated with AgNPs via a modified coaxial electrospinning methodology.
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spelling pubmed-35000322012-11-19 Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process Yu, Deng-Guang Zhou, Jie Chatterton, Nicholas P Li, Ying Huang, Jing Wang, Xia Int J Nanomedicine Original Research BACKGROUND: The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antibacterial effect of Ag can be improved substantially. METHODS: Using polyacrylonitrile (PAN) as the filament-forming polymer matrix, an electrospinnable PAN solution was prepared as the core fluid. A silver nitrate (AgNO(3)) solution was exploited as sheath fluid to carry out the modified coaxial electrospinning process under varied sheath-to-core flow rate ratios. RESULTS: Scanning electron microscopy and transmission electron microscopy demonstrated that the sheath AgNO(3) solution can take a role in reducing the nanofibers’ diameters significantly, a sheath-to-core flow rate ratio of 0.1 and 0.2 resulting in PAN nanofibers with diameters of 380 ± 110 nm and 230 ± 70 nm respectively. AgNPs are well distributed on the surface of PAN nanofibers. The antibacterial experiments demonstrated that these nanofibers show strong antimicrobial activities against Bacillus subtilis Wb800, and Escherichia coli dh5α. CONCLUSION: Coaxial electrospinning with AgNO(3) solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. We report an example of the systematic design, preparation, and application of a novel type of antibacterial material coated with AgNPs via a modified coaxial electrospinning methodology. Dove Medical Press 2012 2012-11-12 /pmc/articles/PMC3500032/ /pubmed/23166437 http://dx.doi.org/10.2147/IJN.S37455 Text en © 2012 Yu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Yu, Deng-Guang
Zhou, Jie
Chatterton, Nicholas P
Li, Ying
Huang, Jing
Wang, Xia
Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_full Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_fullStr Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_full_unstemmed Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_short Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_sort polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500032/
https://www.ncbi.nlm.nih.gov/pubmed/23166437
http://dx.doi.org/10.2147/IJN.S37455
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