Preparation of Fe(3)O(4) magnetic nanoparticles coated with gallic acid for drug delivery

BACKGROUND AND METHODS: Magnetic iron oxide nanoparticles were prepared using a sonochemical method under atmospheric conditions at a Fe(2+) to Fe(3+) molar ratio of 1:2. The iron oxide nanoparticles were subsequently coated with chitosan and gallic acid to produce a core-shell structure. RESULTS: X...

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Detalles Bibliográficos
Autores principales: Dorniani, Dena, Hussein, Mohd Zobir Bin, Kura, Aminu Umar, Fakurazi, Sharida, Shaari, Abdul Halim, Ahmad, Zalinah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500033/
https://www.ncbi.nlm.nih.gov/pubmed/23166439
http://dx.doi.org/10.2147/IJN.S35746
Descripción
Sumario:BACKGROUND AND METHODS: Magnetic iron oxide nanoparticles were prepared using a sonochemical method under atmospheric conditions at a Fe(2+) to Fe(3+) molar ratio of 1:2. The iron oxide nanoparticles were subsequently coated with chitosan and gallic acid to produce a core-shell structure. RESULTS: X-ray diffraction demonstrated that the magnetic nanoparticles were pure Fe(3)O(4) with a cubic inverse spinel structure. Transmission electron microscopy showed that the Fe(3)O(4) nanoparticles were of spherical shape with a mean diameter of 11 nm, compared with 13 nm for the iron oxide-chitosan-gallic acid (FCG) nanocarriers. CONCLUSION: The magnetic nanocarrier enhanced the thermal stability of the drug, gallic acid. Release of the active drug from the FCG nanocarrier was found to occur in a controlled manner. The gallic acid and FCG nanoparticles were not toxic in a normal human fibroblast (3T3) line, and anticancer activity was higher in HT29 than MCF7 cell lines.

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