The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

Amorphous solid dispersions (ASDs) are a promising formulation approach for poorly soluble active pharmaceutical ingredients (APIs), because they ideally enhance both dissolution rate and solubility. However, the mechanism behind this is not understood in detail. In the present study, we investigate...

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Detalles Bibliográficos
Autores principales: Frank, Kerstin J, Westedt, Ulrich, Rosenblatt, Karin M, Hölig, Peter, Rosenberg, Jörg, Mägerlein, Markus, Fricker, Gert, Brandl, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500034/
https://www.ncbi.nlm.nih.gov/pubmed/23166440
http://dx.doi.org/10.2147/IJN.S36571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500034/
https://www.ncbi.nlm.nih.gov/pubmed/23166440
http://dx.doi.org/10.2147/IJN.S36571

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