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The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility
Amorphous solid dispersions (ASDs) are a promising formulation approach for poorly soluble active pharmaceutical ingredients (APIs), because they ideally enhance both dissolution rate and solubility. However, the mechanism behind this is not understood in detail. In the present study, we investigate...
Autores principales: | Frank, Kerstin J, Westedt, Ulrich, Rosenblatt, Karin M, Hölig, Peter, Rosenberg, Jörg, Mägerlein, Markus, Fricker, Gert, Brandl, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500034/ https://www.ncbi.nlm.nih.gov/pubmed/23166440 http://dx.doi.org/10.2147/IJN.S36571 |
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