Conservation of the three-dimensional structure in non-homologous or unrelated proteins

In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed simil...

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Autores principales: Sousounis, Konstantinos, Haney, Carl E, Cao, Jin, Sunchu, Bharath, Tsonis, Panagiotis A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500211/
https://www.ncbi.nlm.nih.gov/pubmed/23244440
http://dx.doi.org/10.1186/1479-7364-6-10
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author Sousounis, Konstantinos
Haney, Carl E
Cao, Jin
Sunchu, Bharath
Tsonis, Panagiotis A
author_facet Sousounis, Konstantinos
Haney, Carl E
Cao, Jin
Sunchu, Bharath
Tsonis, Panagiotis A
author_sort Sousounis, Konstantinos
collection PubMed
description In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence.
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spelling pubmed-35002112012-11-17 Conservation of the three-dimensional structure in non-homologous or unrelated proteins Sousounis, Konstantinos Haney, Carl E Cao, Jin Sunchu, Bharath Tsonis, Panagiotis A Hum Genomics Review In this review, we examine examples of conservation of protein structural motifs in unrelated or non-homologous proteins. For this, we have selected three DNA-binding motifs: the histone fold, the helix-turn-helix motif, and the zinc finger, as well as the globin-like fold. We show that indeed similar structures exist in unrelated proteins, strengthening the concept that three-dimensional conservation might be more important than the primary amino acid sequence. BioMed Central 2012-08-02 /pmc/articles/PMC3500211/ /pubmed/23244440 http://dx.doi.org/10.1186/1479-7364-6-10 Text en Copyright ©2012 Sousounis et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sousounis, Konstantinos
Haney, Carl E
Cao, Jin
Sunchu, Bharath
Tsonis, Panagiotis A
Conservation of the three-dimensional structure in non-homologous or unrelated proteins
title Conservation of the three-dimensional structure in non-homologous or unrelated proteins
title_full Conservation of the three-dimensional structure in non-homologous or unrelated proteins
title_fullStr Conservation of the three-dimensional structure in non-homologous or unrelated proteins
title_full_unstemmed Conservation of the three-dimensional structure in non-homologous or unrelated proteins
title_short Conservation of the three-dimensional structure in non-homologous or unrelated proteins
title_sort conservation of the three-dimensional structure in non-homologous or unrelated proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500211/
https://www.ncbi.nlm.nih.gov/pubmed/23244440
http://dx.doi.org/10.1186/1479-7364-6-10
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AT sunchubharath conservationofthethreedimensionalstructureinnonhomologousorunrelatedproteins
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