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Identification of functional DNA variants in the constitutive promoter region of MDM2

Although mutations in the oncoprotein murine double minute 2 (MDM2) are rare, MDM2 gene overexpression has been observed in several human tumors. Given that even modest changes in MDM2 levels might influence the p53 tumor suppressor signaling pathway, we postulated that sequence variation in the pro...

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Detalles Bibliográficos
Autores principales:	Lalonde, Marie-Eve, Ouimet, Manon, Larivière, Mathieu, Kritikou, Ekaterini A, Sinnett, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500213/ https://www.ncbi.nlm.nih.gov/pubmed/23244604 http://dx.doi.org/10.1186/1479-7364-6-15

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