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Metformin Reduces Hepatic Expression of SIRT3, the Mitochondrial Deacetylase Controlling Energy Metabolism

Metformin inhibits ATP production in mitochondria and this may be involved in the anti-hyperglycemic effects of the drug. Sirtuin 3 (SIRT3) is a mitochondrial protein deacetylase that regulates the function of the electron transport chain and maintains basal ATP yield. We hypothesized that metformin...

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Detalles Bibliográficos
Autores principales:	Buler, Marcin, Aatsinki, Sanna-Mari, Izzi, Valerio, Hakkola, Jukka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500349/ https://www.ncbi.nlm.nih.gov/pubmed/23166782 http://dx.doi.org/10.1371/journal.pone.0049863

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