Comparative Genomics Guided Discovery of Two Missing Archaeal Enzyme Families Involved in the Biosynthesis of the Pterin Moiety of Tetrahydromethanopterin and Tetrahydrofolate

[Image: see text] C-1 carriers are essential cofactors in all domains of life, and in Archaea, these can be derivatives of tetrahydromethanopterin (H(4)-MPT) or tetrahydrofolate (H(4)-folate). Their synthesis requires 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) as the precursor, but the n...

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Detalles Bibliográficos
Autores principales: Crécy-Lagard, Valérie de, Phillips, Gabriela, Grochowski, Laura L., Yacoubi, Basma El, Jenney, Francis, Adams, Michael W. W., Murzin, Alexey G., White, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500442/
https://www.ncbi.nlm.nih.gov/pubmed/22931285
http://dx.doi.org/10.1021/cb300342u

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500442/
https://www.ncbi.nlm.nih.gov/pubmed/22931285
http://dx.doi.org/10.1021/cb300342u

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