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Comparative Genomics Guided Discovery of Two Missing Archaeal Enzyme Families Involved in the Biosynthesis of the Pterin Moiety of Tetrahydromethanopterin and Tetrahydrofolate
[Image: see text] C-1 carriers are essential cofactors in all domains of life, and in Archaea, these can be derivatives of tetrahydromethanopterin (H(4)-MPT) or tetrahydrofolate (H(4)-folate). Their synthesis requires 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) as the precursor, but the n...
Autores principales: | Crécy-Lagard, Valérie de, Phillips, Gabriela, Grochowski, Laura L., Yacoubi, Basma El, Jenney, Francis, Adams, Michael W. W., Murzin, Alexey G., White, Robert H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2012
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500442/ https://www.ncbi.nlm.nih.gov/pubmed/22931285 http://dx.doi.org/10.1021/cb300342u |
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