Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In t...

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Detalles Bibliográficos
Autores principales: Hassanzadeh, F., Khajouei, M. Rahmani, Hakimelahi, G.H., Jafari, E., Khodarahmi, G.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500554/
https://www.ncbi.nlm.nih.gov/pubmed/23181076
Descripción
Sumario:Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, (1)HNMR and Mass spectra.

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