Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In t...

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Detalles Bibliográficos
Autores principales: Hassanzadeh, F., Khajouei, M. Rahmani, Hakimelahi, G.H., Jafari, E., Khodarahmi, G.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500554/
https://www.ncbi.nlm.nih.gov/pubmed/23181076
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author Hassanzadeh, F.
Khajouei, M. Rahmani
Hakimelahi, G.H.
Jafari, E.
Khodarahmi, G.A.
author_facet Hassanzadeh, F.
Khajouei, M. Rahmani
Hakimelahi, G.H.
Jafari, E.
Khodarahmi, G.A.
author_sort Hassanzadeh, F.
collection PubMed
description Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, (1)HNMR and Mass spectra.
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spelling pubmed-35005542012-11-23 Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives Hassanzadeh, F. Khajouei, M. Rahmani Hakimelahi, G.H. Jafari, E. Khodarahmi, G.A. Res Pharm Sci Original Article Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, (1)HNMR and Mass spectra. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3500554/ /pubmed/23181076 Text en Copyright: © Journal of Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hassanzadeh, F.
Khajouei, M. Rahmani
Hakimelahi, G.H.
Jafari, E.
Khodarahmi, G.A.
Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
title Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
title_full Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
title_fullStr Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
title_full_unstemmed Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
title_short Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
title_sort synthesis of some new 2,3-disubstituted-4(3h)quinazolinone derivatives
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500554/
https://www.ncbi.nlm.nih.gov/pubmed/23181076
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