Mutations in Isocitrate Dehydrogenase 1 and 2 Occur Frequently in Intrahepatic Cholangiocarcinomas and Share Hypermethylation Targets with Glioblastomas

Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, have been reported in gliomas, myeloid leukemias, chondrosarcomas, and thyroid cancer. We discovered IDH1 and IDH2 mutations in 34 of 326 (10%) intrahepatic cholangiocarcinomas. Tumor with mutations in IDH1 or IDH2 had lower 5-...

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Detalles Bibliográficos
Autores principales: Wang, Pu, Dong, Qiongzhu, Zhang, Chong, Kuan, Pei-Fen, Liu, Yufeng, Jeck, William R., Andersen, Jesper B., Jiang, Wenqing, Savich, Gleb L., Tan, Ting-Xu, Auman, J. Todd, Hoskins, Janelle M., Misher, Anne D., Moser, Catherine D., Yourstone, Scott M., Kim, Jin Woo, Cibulskis, Kristian, Getz, Gad, Hunt, Heike V., Thorgeirsson, Snorri S., Roberts, Lewis R., Ye, Dan, Guan, Kun-Liang, Xiong, Yue, Qin, Lun-Xiu, Chiang, Derek Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500578/
https://www.ncbi.nlm.nih.gov/pubmed/22824796
http://dx.doi.org/10.1038/onc.2012.315

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