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Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug

Epithelial–mesenchymal transition (EMT) is a complex process which occurs during organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways connecting the physiological and pathological functions of EMT need to be better defined. Here we show that the transcription facto...

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Autores principales: Chakrabarti, Rumela, Hwang, Julie, Blanco, Mario Andres, Wei, Yong, Lukačišin, Martin, Romano, Rose-Anne, Smalley, Kirsten, Liu, Song, Yang, Qifeng, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Haffty, Bruce G., Sinha, Satrajit, Kang, Yibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500637/
https://www.ncbi.nlm.nih.gov/pubmed/23086238
http://dx.doi.org/10.1038/ncb2607
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author Chakrabarti, Rumela
Hwang, Julie
Blanco, Mario Andres
Wei, Yong
Lukačišin, Martin
Romano, Rose-Anne
Smalley, Kirsten
Liu, Song
Yang, Qifeng
Ibrahim, Toni
Mercatali, Laura
Amadori, Dino
Haffty, Bruce G.
Sinha, Satrajit
Kang, Yibin
author_facet Chakrabarti, Rumela
Hwang, Julie
Blanco, Mario Andres
Wei, Yong
Lukačišin, Martin
Romano, Rose-Anne
Smalley, Kirsten
Liu, Song
Yang, Qifeng
Ibrahim, Toni
Mercatali, Laura
Amadori, Dino
Haffty, Bruce G.
Sinha, Satrajit
Kang, Yibin
author_sort Chakrabarti, Rumela
collection PubMed
description Epithelial–mesenchymal transition (EMT) is a complex process which occurs during organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways connecting the physiological and pathological functions of EMT need to be better defined. Here we show that the transcription factor Elf5, a key regulator of mammary gland alveologenesis, controls EMT in both mammary gland development and metastasis. We uncovered this role of Elf5 through analyses of Elf5 conditional knockout animals, various in vitro and in vivo models of EMT and metastasis, an MMTV-neu transgenic model of mammary tumor progression, and clinical breast cancer samples. Furthermore, we demonstrate that Elf5 suppresses EMT by directly repressing the transcription of Snail2/Slug, a master regulator of mammary stem cells and a known inducer of EMT. These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer.
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spelling pubmed-35006372013-05-01 Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug Chakrabarti, Rumela Hwang, Julie Blanco, Mario Andres Wei, Yong Lukačišin, Martin Romano, Rose-Anne Smalley, Kirsten Liu, Song Yang, Qifeng Ibrahim, Toni Mercatali, Laura Amadori, Dino Haffty, Bruce G. Sinha, Satrajit Kang, Yibin Nat Cell Biol Article Epithelial–mesenchymal transition (EMT) is a complex process which occurs during organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways connecting the physiological and pathological functions of EMT need to be better defined. Here we show that the transcription factor Elf5, a key regulator of mammary gland alveologenesis, controls EMT in both mammary gland development and metastasis. We uncovered this role of Elf5 through analyses of Elf5 conditional knockout animals, various in vitro and in vivo models of EMT and metastasis, an MMTV-neu transgenic model of mammary tumor progression, and clinical breast cancer samples. Furthermore, we demonstrate that Elf5 suppresses EMT by directly repressing the transcription of Snail2/Slug, a master regulator of mammary stem cells and a known inducer of EMT. These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer. 2012-10-21 2012-11 /pmc/articles/PMC3500637/ /pubmed/23086238 http://dx.doi.org/10.1038/ncb2607 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Chakrabarti, Rumela
Hwang, Julie
Blanco, Mario Andres
Wei, Yong
Lukačišin, Martin
Romano, Rose-Anne
Smalley, Kirsten
Liu, Song
Yang, Qifeng
Ibrahim, Toni
Mercatali, Laura
Amadori, Dino
Haffty, Bruce G.
Sinha, Satrajit
Kang, Yibin
Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
title Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
title_full Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
title_fullStr Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
title_full_unstemmed Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
title_short Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
title_sort elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing snail2/slug
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500637/
https://www.ncbi.nlm.nih.gov/pubmed/23086238
http://dx.doi.org/10.1038/ncb2607
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