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Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug
Epithelial–mesenchymal transition (EMT) is a complex process which occurs during organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways connecting the physiological and pathological functions of EMT need to be better defined. Here we show that the transcription facto...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500637/ https://www.ncbi.nlm.nih.gov/pubmed/23086238 http://dx.doi.org/10.1038/ncb2607 |
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author | Chakrabarti, Rumela Hwang, Julie Blanco, Mario Andres Wei, Yong Lukačišin, Martin Romano, Rose-Anne Smalley, Kirsten Liu, Song Yang, Qifeng Ibrahim, Toni Mercatali, Laura Amadori, Dino Haffty, Bruce G. Sinha, Satrajit Kang, Yibin |
author_facet | Chakrabarti, Rumela Hwang, Julie Blanco, Mario Andres Wei, Yong Lukačišin, Martin Romano, Rose-Anne Smalley, Kirsten Liu, Song Yang, Qifeng Ibrahim, Toni Mercatali, Laura Amadori, Dino Haffty, Bruce G. Sinha, Satrajit Kang, Yibin |
author_sort | Chakrabarti, Rumela |
collection | PubMed |
description | Epithelial–mesenchymal transition (EMT) is a complex process which occurs during organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways connecting the physiological and pathological functions of EMT need to be better defined. Here we show that the transcription factor Elf5, a key regulator of mammary gland alveologenesis, controls EMT in both mammary gland development and metastasis. We uncovered this role of Elf5 through analyses of Elf5 conditional knockout animals, various in vitro and in vivo models of EMT and metastasis, an MMTV-neu transgenic model of mammary tumor progression, and clinical breast cancer samples. Furthermore, we demonstrate that Elf5 suppresses EMT by directly repressing the transcription of Snail2/Slug, a master regulator of mammary stem cells and a known inducer of EMT. These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer. |
format | Online Article Text |
id | pubmed-3500637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-35006372013-05-01 Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug Chakrabarti, Rumela Hwang, Julie Blanco, Mario Andres Wei, Yong Lukačišin, Martin Romano, Rose-Anne Smalley, Kirsten Liu, Song Yang, Qifeng Ibrahim, Toni Mercatali, Laura Amadori, Dino Haffty, Bruce G. Sinha, Satrajit Kang, Yibin Nat Cell Biol Article Epithelial–mesenchymal transition (EMT) is a complex process which occurs during organogenesis and in cancer metastasis. Despite recent progress, the molecular pathways connecting the physiological and pathological functions of EMT need to be better defined. Here we show that the transcription factor Elf5, a key regulator of mammary gland alveologenesis, controls EMT in both mammary gland development and metastasis. We uncovered this role of Elf5 through analyses of Elf5 conditional knockout animals, various in vitro and in vivo models of EMT and metastasis, an MMTV-neu transgenic model of mammary tumor progression, and clinical breast cancer samples. Furthermore, we demonstrate that Elf5 suppresses EMT by directly repressing the transcription of Snail2/Slug, a master regulator of mammary stem cells and a known inducer of EMT. These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer. 2012-10-21 2012-11 /pmc/articles/PMC3500637/ /pubmed/23086238 http://dx.doi.org/10.1038/ncb2607 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Chakrabarti, Rumela Hwang, Julie Blanco, Mario Andres Wei, Yong Lukačišin, Martin Romano, Rose-Anne Smalley, Kirsten Liu, Song Yang, Qifeng Ibrahim, Toni Mercatali, Laura Amadori, Dino Haffty, Bruce G. Sinha, Satrajit Kang, Yibin Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug |
title | Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug |
title_full | Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug |
title_fullStr | Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug |
title_full_unstemmed | Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug |
title_short | Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug |
title_sort | elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing snail2/slug |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500637/ https://www.ncbi.nlm.nih.gov/pubmed/23086238 http://dx.doi.org/10.1038/ncb2607 |
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