Tumour necrosis factor alpha downregulates human hemojuvelin expression via a novel response element within its promoter

BACKGROUND: Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been identified as a main upstream regulator of hepcidin expression; HJV mutations ar...

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Detalles Bibliográficos
Autores principales: Salama, Mohamed Fouda, Bayele, Henry K, Srai, Surjit SK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500654/
https://www.ncbi.nlm.nih.gov/pubmed/22998440
http://dx.doi.org/10.1186/1423-0127-19-83

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500654/
https://www.ncbi.nlm.nih.gov/pubmed/22998440
http://dx.doi.org/10.1186/1423-0127-19-83

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