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Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil

PURPOSE: To investigate the effect of obesity at the start of adolescence on the prevalence, incidence and maintenance of chest wheezing among individuals aged 11–15 years in a birth cohort in a developing country. METHODS: The seventh follow-up of the 1993 Pelotas birth cohort occurred in 2004 (ind...

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Autores principales: Noal, Ricardo B., Menezes, Ana M.B., Macedo, Silvia E.C., Dumith, Samuel C., Perez-Padilla, Rogelio, Araújo, Cora L.P., Hallal, Pedro C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500686/
https://www.ncbi.nlm.nih.gov/pubmed/23283159
http://dx.doi.org/10.1016/j.jadohealth.2012.08.016
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author Noal, Ricardo B.
Menezes, Ana M.B.
Macedo, Silvia E.C.
Dumith, Samuel C.
Perez-Padilla, Rogelio
Araújo, Cora L.P.
Hallal, Pedro C.
author_facet Noal, Ricardo B.
Menezes, Ana M.B.
Macedo, Silvia E.C.
Dumith, Samuel C.
Perez-Padilla, Rogelio
Araújo, Cora L.P.
Hallal, Pedro C.
author_sort Noal, Ricardo B.
collection PubMed
description PURPOSE: To investigate the effect of obesity at the start of adolescence on the prevalence, incidence and maintenance of chest wheezing among individuals aged 11–15 years in a birth cohort in a developing country. METHODS: The seventh follow-up of the 1993 Pelotas birth cohort occurred in 2004 (individuals aged 10–11 years). Between January and August 2008, the eighth follow-up of the cohort was conducted. All the individuals of the original cohort who were alive (who were then adolescents aged between 14 and 15 years) were targets for the study. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to define wheezing. In addition to the body mass index (BMI), used to define obesity by the World Health Organization (WHO) criteria, we assessed skinfold thickness. RESULTS: From the original cohort, 4,349 individuals were located (85.7% follow-up rate). The prevalence of chest wheezing at 11 and 15 years were 13.5% (95% CI: 12.5%–14.5%) and 12.1% (95% CI: 11.1%–13.1%), respectively. The prevalence of wheezing at both times was 4.5% (95% CI: 3.9%–5.1%) and the incidence of wheezing was 7.5% (95% CI: 6.7%–8.3%). Independent of the effect of various confounding variables, the prevalence of wheezing at 15 years was 50% greater among obese individuals than among eutrophic individuals at 11 years (RR 1.53; 95% CI: 1.14–2.05). The greater the skinfold tertile at 11 years, the higher the prevalence of wheezing at 15 years was (p = .011). Weight status and skinfolds did not present any association with incident wheezing. After controlling for confounding factors, the risk of persistent wheezing among obese individuals at 11 years was 1.82 (95% CI: 1.30–2.54). CONCLUSIONS: Since obesity at the start of adolescence is associated with asthma symptom persistence, prevention and treatment of obesity may reduce avoidable healthcare costs and disease burden.
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spelling pubmed-35006862012-12-31 Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil Noal, Ricardo B. Menezes, Ana M.B. Macedo, Silvia E.C. Dumith, Samuel C. Perez-Padilla, Rogelio Araújo, Cora L.P. Hallal, Pedro C. J Adolesc Health Original Article PURPOSE: To investigate the effect of obesity at the start of adolescence on the prevalence, incidence and maintenance of chest wheezing among individuals aged 11–15 years in a birth cohort in a developing country. METHODS: The seventh follow-up of the 1993 Pelotas birth cohort occurred in 2004 (individuals aged 10–11 years). Between January and August 2008, the eighth follow-up of the cohort was conducted. All the individuals of the original cohort who were alive (who were then adolescents aged between 14 and 15 years) were targets for the study. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to define wheezing. In addition to the body mass index (BMI), used to define obesity by the World Health Organization (WHO) criteria, we assessed skinfold thickness. RESULTS: From the original cohort, 4,349 individuals were located (85.7% follow-up rate). The prevalence of chest wheezing at 11 and 15 years were 13.5% (95% CI: 12.5%–14.5%) and 12.1% (95% CI: 11.1%–13.1%), respectively. The prevalence of wheezing at both times was 4.5% (95% CI: 3.9%–5.1%) and the incidence of wheezing was 7.5% (95% CI: 6.7%–8.3%). Independent of the effect of various confounding variables, the prevalence of wheezing at 15 years was 50% greater among obese individuals than among eutrophic individuals at 11 years (RR 1.53; 95% CI: 1.14–2.05). The greater the skinfold tertile at 11 years, the higher the prevalence of wheezing at 15 years was (p = .011). Weight status and skinfolds did not present any association with incident wheezing. After controlling for confounding factors, the risk of persistent wheezing among obese individuals at 11 years was 1.82 (95% CI: 1.30–2.54). CONCLUSIONS: Since obesity at the start of adolescence is associated with asthma symptom persistence, prevention and treatment of obesity may reduce avoidable healthcare costs and disease burden. Elsevier 2012-12 /pmc/articles/PMC3500686/ /pubmed/23283159 http://dx.doi.org/10.1016/j.jadohealth.2012.08.016 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Original Article
Noal, Ricardo B.
Menezes, Ana M.B.
Macedo, Silvia E.C.
Dumith, Samuel C.
Perez-Padilla, Rogelio
Araújo, Cora L.P.
Hallal, Pedro C.
Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil
title Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil
title_full Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil
title_fullStr Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil
title_full_unstemmed Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil
title_short Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil
title_sort is obesity a risk factor for wheezing among adolescents? a prospective study in southern brazil
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500686/
https://www.ncbi.nlm.nih.gov/pubmed/23283159
http://dx.doi.org/10.1016/j.jadohealth.2012.08.016
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